Preoperative lymph-node staging of invasive urothelial bladder cancer with 18F-fluorodeoxyglucose positron emission tomography/computed axial tomography and magnetic resonance imaging:correlation with histopathology
| Autor: | Oke Gerke, Morten Riehmann, Birgitte Svolgaard, Niels Marcussen, Per Holt, Thor Knak Jensen, Kirsten Bouchelouche |
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| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: |
Male
medicine.medical_specialty Urology Adenocarcinoma Preoperative care Sensitivity and Specificity Metastasis Fluorodeoxyglucose F18 Preoperative Care medicine Carcinoma Journal Article Humans Comparative Study Aged Neoplasm Staging Retrospective Studies Carcinoma Transitional Cell Bladder cancer medicine.diagnostic_test business.industry Magnetic resonance imaging Middle Aged medicine.disease Prognosis Magnetic Resonance Imaging Urinary Bladder Neoplasms Nephrology Positron emission tomography Lymphatic Metastasis Positron-Emission Tomography Carcinoma Squamous Cell Histopathology Female Tomography Radiology Lymph Nodes Urothelium business Tomography X-Ray Computed |
| Zdroj: | Jensen, T K, Holt, P, Gerke, O, Riehmann, M, Svolgaard, B, Marcussen, N & Bouchelouche, K 2011, ' Preoperative lymph-node staging of invasive urothelial bladder cancer with 18F-fluorodeoxyglucose positron emission tomography/computed axial tomography and magnetic resonance imaging : correlation with histopathology ', Scandinavian Journal of Urology and Nephrology. Supplement, vol. 45, no. 2, pp. 122-8 . https://doi.org/10.3109/00365599.2010.544672 |
| DOI: | 10.3109/00365599.2010.544672 |
| Popis: | OBJECTIVE: The treatment and prognosis of bladder cancer are based on the depth of primary tumour invasion and the presence of metastases. A highly accurate preoperative tumour, node, metastasis (TNM) staging is critical to proper patient management and treatment. This study retrospectively investigated the value of ¹⁸F-fluorodeoxyglucose (FDG) positron emission tomography/computed axial tomography (¹⁸F-FDG PET/CT) and magnetic resonance imaging (MRI) for preoperative N staging of bladder cancer. Material and methods. From June 2006 to January 2008, 48 consecutive patients diagnosed with bladder cancer were referred to preoperative staging including MRI and ¹⁸F-FDG PET/CT. Eighteen out of 48 patients underwent radical cystoprostatectomy including removal of lymph nodes for histology, and were included in the study. Values of ¹⁸F-FDG PET/CT and MRI for regional N staging were compared to histopathology findings, the gold standard. Results. ¹⁸F-FDG PET/CT and MRI were performed in 18 patients. The specificities for detection of lymph-node metastases for MRI and ¹⁸F-FDG PET/CT were 80% (n = 15) and 93.33% (n = 15), respectively. The negative predictive values were 80% (n = 15) and 87.5% (n = 16) for MRI and ¹⁸F-FDG PET/CT, respectively. The differences in specificity and negative predictive values were not statistically significant. Conclusions. No significant statistical difference between ¹⁸F-FDG PET/CT and MRI for preoperative N staging of urothelial bladder cancer was found in the study. However, the trend of the data indicates an advantage of ¹⁸F-FDG PET/CT over MRI. Larger prospective studies are needed to elucidate the role of ¹⁸F-FDG PET/CT in N staging of bladder cancer. |
| Databáze: | OpenAIRE |
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