Calvarial bone wound healing: a comparison between carbide and diamond drills, Er:YAG and Femtosecond lasers with or without BMP-7
| Autor: | Dayne Miller, George K.B. Sándor, Cameron M L Clokie, Bruno Girard, David Wilson, Sean A.F. Peel, Martin Cloutier |
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| Rok vydání: | 2010 |
| Předmět: |
Time Factors
Materials science genetic structures Bone Morphogenetic Protein 7 medicine.medical_treatment Dentistry Calvaria Lasers Solid-State Bone healing law.invention Parietal Bone Mice Imaging Three-Dimensional law Image Processing Computer-Assisted medicine Animals General Dentistry Mice Inbred ICR Wound Healing Laser ablation business.industry Lasers Equipment Design X-Ray Microtomography equipment and supplies Laser Ablation Carbon Bone morphogenetic protein 7 medicine.anatomical_structure Otorhinolaryngology Femtosecond Female Surgery Laser Therapy Diamond Oral Surgery Wound healing business Craniotomy |
| Zdroj: | Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology. 110:720-728 |
| ISSN: | 1079-2104 |
| Popis: | Objective. This study compared the healing of 2 laser ablation units, erbium YAG and femtosecond lasers versus conventional mechanical cutting with carbide and diamond drills to explore future applications for bone surgery. The effects of laser or mechanical ablation combined with rhBMP-7 were also investigated. Methods and materials. Following defect standardization, a full-thickness circular defect was created on the parietal bones of 160 mice divided into 4 groups: carbide drill, diamond drill, erbium YAG laser, and femtosecond laser. Each of the 4 ablation groups was treated with and without BMP 7. Hard tissue healing was assessed using microcomputerized tomography at 3 and 12 weeks postsurgical time points. Results. The femtosecond laser created wounds that showed slightly delayed bone healing during the observation period when compared with mechanical drilling, although the difference was not statistically significant. The Er:YAG laser showed a healing rate similar to that of the mechanically ablated groups. When BMP 7 was added to the surgical sites, bone wound closure occurred at a similar rate in all test groups. Conclusions. The femtosecond and Er:YAG lasers are 2 laser modalities suitable for bone ablation that are comparable to mechanical instrumentation in terms of bone healing. This study suggested that BMP-7 may be used to enhance bone healing with success regardless of the ablative modality used, whether laser or mechanical drilling. (Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2010;110:720-728) |
| Databáze: | OpenAIRE |
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