Use of Oseltamivir During Influenza Outbreaks in Ontario Nursing Homes, 1999â2000
| Autor: | Susan K. Bowles, Wayne Lee, Andrew E. Simor, Mary Vearncombe, Mark Loeb, Susan Tamblyn, Margaret Fearon, Yan Li, Allison McGeer, null The Oseltamivir Compassionate Use P |
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| Rok vydání: | 2002 |
| Předmět: |
Male
medicine.medical_specialty Oseltamivir Nausea medicine.drug_class Antibiotics Antiviral Agents Disease Outbreaks chemistry.chemical_compound Acetamides Influenza Human Amantadine medicine Humans Intensive care medicine Aged Aged 80 and over Ontario business.industry virus diseases Outbreak Middle Aged medicine.disease Long-Term Care Nursing Homes Diarrhea Pneumonia Treatment Outcome chemistry Influenza Vaccines Emergency medicine Female Viral disease Geriatrics and Gerontology medicine.symptom business medicine.drug |
| Zdroj: | Journal of the American Geriatrics Society. 50:608-616 |
| ISSN: | 1532-5415 0002-8614 |
| DOI: | 10.1046/j.1532-5415.2002.50153.x |
| Popis: | OBJECTIVES: To describe the experience of Ontario long-term care facilities that used oseltamivir during influenza outbreaks in 1999/2000. DESIGN: Case series. SETTING: Ten Ontario long-term care facilities for older people and their residents. PARTICIPANTS: Older residents of long-term care facilities. INTERVENTION: Oseltamivir for treatment or prophylaxis during 11 influenza outbreaks in 1999/2000. MEASUREMENTS: Control of outbreaks; pneumonia, hospitalization, and death complicating acute influenza. RESULTS: All outbreaks were due to influenza A//H3N2/Sydney/05/97. One facility elected to use oseltamivir for treatment and amantadine for prophylaxis. The remaining nine facilities (10 outbreaks) recommended oseltamivir for treatment and prophylaxis (after amantadine failure in five and as primary prophylaxis in five). Use of oseltamivir was associated with termination of the outbreak in all eight evaluable outbreaks. Overall, 178/185 (96%) case-residents met the case definition of influenza and had complete data for evaluation. Of these, 63 (35%) were treated with antibiotics, 37 (21%) were diagnosed with pneumonia, 19 (11%) were hospitalized, and 16 (9%) died. Compared with residents receiving no therapy or who became ill while taking amantadine, residents who received oseltamivir within 48 hours of the onset of symptoms were less likely to be prescribed antibiotics, to be hospitalized, or to die (P |
| Databáze: | OpenAIRE |
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