Parallel Synthesis of 1,6-Disubstituted-1,2,4-triazin-3-ones on Solid-Phase
Autor: | Richard A. Houghten, Miao Hu, Wei Huang, Yongping Yu, Marc A. Giulianotti |
---|---|
Rok vydání: | 2013 |
Předmět: | |
Zdroj: | ACS Combinatorial Science. 15:335-339 |
ISSN: | 2156-8944 2156-8952 |
Popis: | A parallel solid-phase synthesis of 1,6-disubstituted-1,2,4-triazin-3-ones from MBHA resin is described. The reduction of resin-bound nitrosamino acids provides hydrazines efficiently without affecting the amide bond. The trityl protected hydrazine is then reduced with borane, and cyclized with 1,1-carbonyldiimidazole. The desired products are cleaved from their solid support and obtained in good yield and purity. This methodology is of value for the rapid parallel preparation of these potentially bioactive molecules. |
Databáze: | OpenAIRE |
Externí odkaz: |