Critically ill patients with COVID-19 in Tokyo, Japan: a single-center case series
| Autor: | Hiroki Kojima, Mayu Hikone, Tatsunori Oyabu, Sentaro Iwabuchi, Yusuke Kuwahara, Takuya Washino, Atsushi Kosaka, Satoshi Miike, Fukumi Nakamura-Uchiyama, Takuto Ishida, Naoya Sakamoto |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Male medicine.medical_treatment BMI body mass index Comorbidity Single Center RT-PCR reverse transcriptase polymerase chain reaction 0302 clinical medicine Japan Medicine Pharmacology (medical) 030212 general & internal medicine Cause of death COVID-19 coronavirus disease 2019 Aged 80 and over Mortality rate MV mechanical ventilation Middle Aged ICU intensive care unit CT computed tomography Infectious Diseases Treatment Outcome Hypertension Female Original Article Respiratory Insufficiency Microbiology (medical) Adult medicine.medical_specialty Critical Illness 030106 microbiology mechanical ventilation SARS-CoV-2 severe acute respiratory syndrome coronavirus 2 03 medical and health sciences coronavirus disease 2019 Extracorporeal Membrane Oxygenation Intensive care Extracorporeal membrane oxygenation Diabetes Mellitus Humans Obesity Tokyo ARDS acute respiratory distress syndrome IQR interquartile range Aged Retrospective Studies Mechanical ventilation business.industry SARS-CoV-2 COVID-19 Overweight Respiration Artificial PEEP positive-end expiratory pressure Respiratory failure COPD chronic obstructive pulmonary disease Emergency medicine business SD standard deviation ECMO extracorporeal membrane oxygenation Case series |
| Zdroj: | Journal of Infection and Chemotherapy |
| ISSN: | 1437-7780 1341-321X |
| Popis: | Introduction We reported, in our previous study, a patient with coronavirus disease 2019 (COVID-19) who was successfully treated with extracorporeal membrane oxygenation. Data on clinical courses and outcomes of critically ill patients with COVID-19 in Japan are limited in the literature. This study aimed to describe the clinical courses and outcomes of critically ill patients with COVID-19 in Tokyo, Japan. Methods This is a single-center case series study. Patients with COVID-19 treated with mechanical ventilation (MV) were reviewed retrospectively. Data on baseline characteristics, in-hospital treatment, and outcomes were collected. Results Between February 2, 2020, and June 30, 2020, 14 critically ill patients with COVID-19 were treated with MV. Most patients were male and had comorbidities, especially hypertension or diabetes; 35.7% were overweight and 21.4% were obese. The majority of the patients had dyspnea on admission. The median duration of MV was 10.5 days, and the 28-day mortality rate was 35.7%. In the four patients with COVID-19 who died, the cause of death was respiratory failure. Conclusions As in previous reports from other countries, the mortality rate of patients with COVID-19 requiring intensive care remains high in Tokyo. Further study on the appropriate timing of MV initiation and specific treatments for critically ill patients with COVID-19 is needed. |
| Databáze: | OpenAIRE |
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