Acute intrahepatic cholestasis accompanied with Chlamydophila pneumoniae infection
| Autor: | Yuki Shimizu, Fumihiko Kaneko, Hirobumi Kondo, Hide Yoshida, Toshifumi Hibi, Makoto Ohbu, Kumiko Tahara, Megumi Toyoda-Akui, Masaya Oda, Hajime Takeuchi, Hiroaki Yokomori, Tadashi Motoori |
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| Rok vydání: | 2011 |
| Předmět: |
Male
Enlarged liver Pathology medicine.medical_specialty Fever Minocycline Cholestasis Intrahepatic Biology medicine.disease_cause Pathology and Forensic Medicine Bile canaliculus Erythema Nodosum Cholestasis medicine Humans Aspartate Aminotransferases Chlamydophila Infections Lung Molecular Biology Erythema nodosum medicine.diagnostic_test Alanine Transaminase General Medicine Chlamydophila pneumoniae Middle Aged Jaundice medicine.disease Antibodies Bacterial Anti-Bacterial Agents Jaundice Obstructive Liver Liver biopsy medicine.symptom Liver function tests |
| Zdroj: | Medical Molecular Morphology. 44:52-57 |
| ISSN: | 1860-1499 1860-1480 |
| DOI: | 10.1007/s00795-010-0535-y |
| Popis: | We report a case of Chlamydophila (C.) pneumoniae infection presenting with fever and rapid intrahepatic cholestasis. A 63-year-old man had a week-long history of intermittent high fever and rapidly progressive jaundice with atypical erythema. The results of liver function tests were recorded. The results of all serological tests were negative; the IgM, IgG, and IgA titers for C. pneumoniae had increased, which indicates a C. pneumoniae infection. The patient's fever and liver dysfunction improved upon administration of minocycline. Light microscopic findings showed the presence of enlarged liver cells with clear cytoplasm, a few mitotic figures, multinucleated cells, and bile cholestasis. The electron microscopic appearance of liver biopsy showed that bile canaliculi exhibited intrahepatic forms of cholestasis. From the results of light and electron microscopy, we inferred atypical intrahepatic cholestasis, probably resulting from the C. pneumoniae infection. |
| Databáze: | OpenAIRE |
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