Total Synthesis and Conformational Analysis of the Antifungal Agent (−)-PF1163B

Autor:	Fodil Bouazza, Christian Bachmann, Brigitte Renoux, Jean-Pierre Gesson
Rok vydání:	2003
Předmět:	Antifungal Antifungal Agents Macrocyclic Compounds Magnetic Resonance Spectroscopy medicine.drug_class Stereochemistry Antibiotics Molecular Conformation Methyltyrosines Stereoisomerism Biochemistry Streptomyces Heterocyclic Compounds 1-Ring chemistry.chemical_compound Amide medicine Salt metathesis reaction Physical and Theoretical Chemistry Molecular Structure biology Antifungal antibiotic Organic Chemistry Total synthesis General Medicine Nuclear magnetic resonance spectroscopy biology.organism_classification Combinatorial chemistry chemistry Cyclization Monoterpenes Derivative (chemistry)
Zdroj:	Organic Letters. 5:4049-4052
ISSN:	1523-7052 1523-7060
DOI:	10.1021/ol035309c
Popis:	[reaction: see text]. (-)-PF1163B, a new macrocyclic antifungal antibiotic isolated from Streptomyces sp., has been prepared in eight steps from (S)-citronellene. The key step is a ring-closing metathesis reaction of an ester and amide derivative obtained from a substituted N-methyl-l-tyrosine.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e39fd43972dddfcf4cbc9be1a0d756c9 https://doi.org/10.1021/ol035309c Zobrazit plný text záznamu