Enzyme Prodrug Therapy with Photo-Cross-Linkable Anti-EGFR Affibodies Conjugated to Upconverting Nanoparticles

Autor:	Shambojit Roy, Shane D. Curry, Conrad Corbella Bagot, Evan N. Mueller, Abdulrahman M. Mansouri, Wounjhang Park, Jennifer N. Cha, Andrew P. Goodwin
Rok vydání:	2022
Předmět:	EGF Family of Proteins General Engineering Flucytosine Mice Nude General Physics and Astronomy Antineoplastic Agents Cytosine Deaminase Mice Cell Line Tumor Humans Animals Nanoparticles Prodrugs General Materials Science Fluorouracil Caco-2 Cells
Zdroj:	ACS Nano. 16:15873-15883
ISSN:	1936-086X 1936-0851
DOI:	10.1021/acsnano.2c02558
Popis:	In this work, we demonstrate that a photo-cross-linkable conjugate of upconverting nanoparticles and cytosine deaminase can catalyze prodrug conversion specifically at tumor sites
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e39e442c13d4a157e6d1108ced35ac54 https://doi.org/10.1021/acsnano.2c02558 Zobrazit plný text záznamu