Epigenetic Regulations of AhR in the Aspect of Immunomodulation
| Autor: | Joanna Łapczuk-Romańska, Anna Wajda, Agnieszka Paradowska-Gorycka |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Review
Biology medicine.disease_cause immunomodulation Catalysis Autoimmunity Autoimmune Diseases Epigenesis Genetic Inorganic Chemistry lcsh:Chemistry microRNA medicine Animals Humans Epigenetics Physical and Theoretical Chemistry Molecular Biology lcsh:QH301-705.5 Spectroscopy Autoimmune disease Regulation of gene expression Organic Chemistry AhR autoimmunity General Medicine DNA Methylation medicine.disease Computer Science Applications Chromatin Histone Gene Expression Regulation Receptors Aryl Hydrocarbon lcsh:Biology (General) lcsh:QD1-999 DNA methylation biology.protein Neuroscience epigenetic |
| Zdroj: | International Journal of Molecular Sciences International Journal of Molecular Sciences, Vol 21, Iss 6404, p 6404 (2020) |
| ISSN: | 1422-0067 |
| Popis: | Environmental factors contribute to autoimmune disease manifestation, and as regarded today, AhR has become an important factor in studies of immunomodulation. Besides immunological aspects, AhR also plays a role in pharmacological, toxicological and many other physiological processes such as adaptive metabolism. In recent years, epigenetic mechanisms have provided new insight into gene regulation and reveal a new contribution to autoimmune disease pathogenesis. DNA methylation, histone modifications, chromatin alterations, microRNA and consequently non-genetic changes in phenotypes connect with environmental factors. Increasing data reveals AhR cross-roads with the most significant in immunology pathways. Although study on epigenetic modulations in autoimmune diseases is still not well understood, therefore future research will help us understand their pathophysiology and help to find new therapeutic strategies. Present literature review sheds the light on the common ground between remodeling chromatin compounds and autoimmune antibodies used in diagnostics. In the proposed review we summarize recent findings that describe epigenetic factors which regulate AhR activity and impact diverse immunological responses and pathological changes. |
| Databáze: | OpenAIRE |
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