Impact of laterality and mucinous histology on relapse-free and overall survival in a registry-based colon cancer series

Autor: Maria Michiara, Enrico Maria Silini, Annalisa Gilli, Guido Rindi, Stefano Cascinu, Matteo Goldoni, Cinzia Azzoni, Letizia Gnetti, Annamaria Giorgi, Laura Manotti, Francesco Leonardi, Lorena Bottarelli, Francesca Negri, P. Sgargi
Přispěvatelé: Negri, F., De Giorgi, A., Gilli, A., Azzoni, C., Bottarelli, L., Gnetti, L., Goldoni, M., Manotti, L., Sgargi, P., Michiara, M., Leonardi, F., Rindi, G., Cascinu, S., Silini, E. M.
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Zdroj: Scientific Reports, Vol 9, Iss 1, Pp 1-9 (2019)
Scientific Reports
ISSN: 2045-2322
Popis: Recent data suggest that tumor laterality and mucinous histology may be clinically relevant. We investigated how both variables impact on the prognosis and the response to therapies in a large population-based cohort of cancer patients. Incidence data, clinical and pathological features, and outcome were systematically collected from the Tumor Registry of Parma over the years 2004–2009. Survival data were modeled by multivariable analysis. 1358 patients affected by stage I–IV colon cancer were considered; 661 (49%) had right-sided and 697 (51%) left-sided tumors. 144 (11%) had mucinous (MAC) and 1214 (89%) non-mucinous (NMAC) histology. MACs and NMACs of the right colon showed no difference in stage distribution, whereas left colon MACs were more frequently in an advanced stage (stage IV) (p = 0.008). Stage IV right colon tumors had a poorer overall survival than stage IV left-sided colon cancers (75th percentile 20 vs 34 months, p
Databáze: OpenAIRE
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