Topical pimecrolimus lacks genotoxicity and cytotoxicity by means of micronucleus erythrocyte rodent assay
| Autor: | Belinda C. Gómez-Meda, Ana Lourdes Zamora-Perez, Martha Barba-Barajas, Guillermo Moisés Zúñiga-González, Vicente Garibaldi-Becerra, Aurelio Flores-García |
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| Rok vydání: | 2011 |
| Předmět: |
Male
Erythrocytes Cell Survival Skin Absorption Health Toxicology and Mutagenesis Biology Administration Cutaneous Toxicology medicine.disease_cause Tacrolimus Ointments Mice Pimecrolimus medicine Animals Cytotoxic T cell Cytotoxicity Micronuclei Chromosome-Defective Skin Pharmacology Mice Inbred BALB C Micronucleus Tests Chemical Health and Safety Public Health Environmental and Occupational Health General Medicine Atopic dermatitis medicine.disease Calcineurin medicine.anatomical_structure Immunology Bone marrow Micronucleus Immunosuppressive Agents Genotoxicity medicine.drug |
| Zdroj: | Drug and Chemical Toxicology. 34:462-466 |
| ISSN: | 1525-6014 0148-0545 |
| Popis: | Topical pimecrolimus is an alternative treatment of atopic dermatitis. However, rare cases of malignancy have been reported with their use. This study was performed to investigate the possible geno- or cytotoxic effect in mouse bone marrow caused by systemic absorption of pimecrolimus 1% cream. In order to determine this, induction of micronucleated erythrocytes (MNE) in mouse peripheral blood was determined after the cutaneous application of three different doses, daily for 5 consecutive days. No differences were found in frequencies of polychromatic erythrocytes, MNE, and micronucleated polychromatic erythrocytes in the different groups of study. In conclusion, under described conditions, no geno- or cytotoxic effects were detected after the cutaneous application of pimecrolimus. |
| Databáze: | OpenAIRE |
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