Prevalence and safety of diazoxide in the neonatal intensive care unit
| Autor: | Tylah Harrison, Colman Freel, Mihai Puia-Dumitrescu, Keyaria D. Gray, Robert Benjamin, C. Michael Cotten, Chandler McMillan, Rachel G. Greenberg, Reese H. Clark, Kathryn Dudash, Daniel K. Benjamin, Carla Escobar |
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| Rok vydání: | 2018 |
| Předmět: |
Male
Pediatrics medicine.medical_specialty Neonatal intensive care unit medicine.medical_treatment Gestational Age Hypoglycemia Article 03 medical and health sciences 0302 clinical medicine Intensive Care Units Neonatal 030225 pediatrics Intensive care Prevalence medicine Diazoxide Humans 030212 general & internal medicine Adverse effect Retrospective Studies business.industry Infant Newborn Obstetrics and Gynecology Gestational age Retrospective cohort study medicine.disease Drug Utilization United States 3. Good health Pediatrics Perinatology and Child Health Female Diuretic business medicine.drug |
| Zdroj: | Journal of perinatology : official journal of the California Perinatal Association |
| ISSN: | 1476-5543 0743-8346 |
| DOI: | 10.1038/s41372-018-0218-4 |
| Popis: | Objective: Diazoxide is used to treat infants with persistent hypoglycemia, but the prevalence of its use and adverse effects are not well described. We report demographic and clinical characteristics of infants treated with diazoxide in neonatal intensive care units (NICUs). Study design: Retrospective cohort study of infants 24–41 weeks’ gestation admitted to 392 NICUs from 1997–2016, comparing characteristics between hypoglycemic infants exposed/not exposed to diazoxide. For diazoxide courses >1 day, we report percentages of infants starting diuretics and/or developing new ventilator/oxygen requirement during therapy. Results: Among 1,249,466 infants, 185,832 had hypoglycemia; 1066/185,832 (0.57%) received diazoxide. Diazoxide use increased over time (p=0.001). Infants receiving diazoxide varied from 0%−14.9% among centers. New diuretic courses were associated with 91/664 (14%), and new oxygen or ventilator requirement during therapy was associated with 64/556 (12%) and 34/647 (5%), respectively. Conclusions: Diazoxide use in NICU settings has increased over time. Infants receiving diazoxide commonly received diuretics. |
| Databáze: | OpenAIRE |
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