Topography of dopamine D-1 and D-2 receptor-mediated rotation after intrastriatal injections of dopamine-related drugs in normosensitive rats
| Autor: | Spiridon Konitsiotis, E. Kafetzopoulos |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
Male
medicine.medical_specialty Corpus Striatum/*drug effects Apomorphine medicine.drug_class Motor Activity Receptors Dopamine chemistry.chemical_compound Dopamine Sulpiride/*pharmacology Internal medicine medicine Animals Injections Intraventricular Pharmacology Analysis of Variance SCH-23390 Behavior Animal Receptors Dopamine D2 Benzazepines/*pharmacology Receptors Dopamine D1 Ventral striatum Dopamine antagonist Rats Inbred Strains Benzazepines Receptor antagonist Corpus Striatum Rats Motor Activity/*drug effects Endocrinology medicine.anatomical_structure Apomorphine/pharmacology chemistry Dopamine receptor Dopamine Antagonists Receptors Dopamine/*drug effects Sulpiride Injections Intraperitoneal Behavior Animal/*drug effects medicine.drug |
| Zdroj: | European Journal of Pharmacology. 179:201-205 |
| ISSN: | 0014-2999 |
| DOI: | 10.1016/0014-2999(90)90419-7 |
| Popis: | Naive rats were challenged systematically with apomorphine after receiving unilateral dorsal or ventral intracaudate injections of the dopamine D-1 receptor antagonist, SCH23390, or the D-2 receptor antagonist, sulpiride. Sulpiride injections into both the dorsal and ventral striatum induced a robust ipsilateral rotation, while SCH23390 elicited a weaker ipsilateral rotation only on injection into the ventral striatum. Both drugs were ineffective in saline-treated rats, although sulpiride injections into the ventral striatum after systemic saline elicited a small ipsilateral preference. The results from this rotational model mediated by normosensitive receptors indicate that only dopamine D-1 receptors in the ventral striatum mediate rotation while D-2 receptors in both striatal regions mediate rotation. A functional dichotomy between these two neostriatal regions is thus proposed. Eur J Pharmacol |
| Databáze: | OpenAIRE |
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