THE MB ISOENZYME OF CREATINE KINASE AS AN INDICATOR OF SEVERITY OF MYOCARDIAL ISCHqMIA
| Autor: | S. Keidar, E. Grenadier, G. Alpan, A Marmor, A. Palant |
|---|---|
| Rok vydání: | 1978 |
| Předmět: |
medicine.medical_specialty
Myocardial ischaemia Myocardial Infarction Infarction Coronary Disease Isozyme Angina Pectoris Angina Internal medicine medicine Humans ST segment cardiovascular diseases Myocardial infarction Creatine Kinase biology Unstable angina business.industry Myocardium General Medicine medicine.disease Isoenzymes Acute Disease biology.protein Cardiology Creatine kinase business |
| Zdroj: | The Lancet. 312:812-814 |
| ISSN: | 0140-6736 |
| DOI: | 10.1016/s0140-6736(78)92590-4 |
| Popis: | 86 patients with ischaemic heart-disease were assessed for the presence of the MB isoenzyme of creatine kinase (C.K.-MB). Raised C.K.-MB levels with normal total C.K. were found in 10 patients with a clinical picture, but no electrocardiographic evidence, of acute myocardial infarction. 4 of these patients later had an infarction, but the remaining 6 have remained undiagnosed. Of 26 patients with unstable angina, 11 (42%) had high levels of C.K.-MB in the presence of normal total C.K. Of 50 patients with effort angina and a positive ergometric stress test, 3 (6%) with crescendo angina had high C.K.-MB levels in the presence of normal total C.K. In patients with angina, myocardial necrosis was excluded by normal serum-myoglobin levels. In both groups with angina, those with raised C.K.-MB levels had a more severe clinical picture, greater depressions of the ST segment, and lower thresholds to ergometry. Raised C.K.-MB. levels may indicate myocardial ischaemia. |
| Databáze: | OpenAIRE |
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