Corticosteroid therapy in IgA nephropathy with minimal change-like lesions: a single-centre cohort study
| Autor: | Jinquan Wang, Caihong Zeng, Zhihong Liu, Chenxia Juan, Qian Huang |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent Anti-Inflammatory Agents Renal function Kidney Function Tests urologic and male genital diseases Gastroenterology Nephropathy Young Adult Heavy proteinuria Prednisone Internal medicine Humans Medicine Minimal change disease Prospective Studies Prospective cohort study Transplantation Proteinuria business.industry Nephrosis Lipoid Remission Induction Glomerulonephritis IGA Middle Aged Prognosis medicine.disease Endocrinology Nephrology Cohort Female medicine.symptom business Biomarkers Follow-Up Studies Glomerular Filtration Rate medicine.drug |
| Zdroj: | Nephrology Dialysis Transplantation. 28:2339-2345 |
| ISSN: | 1460-2385 0931-0509 |
| DOI: | 10.1093/ndt/gft211 |
| Popis: | There is a lack of high-quality evidence that advocates the use of corticosteroids for IgA nephropathy (IgAN) with minimal change-like lesions (also called IgAN with minimal change disease, MCD-IgAN).Twenty-seven biopsy-proven adult MCD-IgAN patients were enrolled. Daily single dose of 1 mg/kg (maximum 60 mg/day) prednisone was given until complete remission (CR), followed by gradually decreasing dosage. The clinical data were collected from baseline up to 12 weeks of treatment (Certification No. 2011NLY-006, Clinical trials gov ID. NCT01451710).The patient cohort consisted of 15 males and 12 females. The mean age of the patients was 29.2 ± 10.8 years (range 18-60 years) at the time when they were subject to renal biopsy. All patients had hypoalbuminaemia (23.7 ± 4.13 g/L) and heavy proteinuria (3.5 g/24 h). Cumulative CR (proteinuria0.4 g/24 h) rates were 3.70, 48.1, 92.6 and 100% after 1, 2, 4 and 8 weeks of treatment, respectively. Two cases relapsed after CR, one at 6 weeks of treatment, likely due to failure to follow the corticosteroid withdrawal schedule, and the other one at 8 weeks of treatment accompanied with an upper respiratory infection. Infection, alanine aminotransferase elevation (2-folds), fasting blood glucose (FBG) elevation (6.2 mmol/L) and hypopotassaemia (3.5 mmol/L) occurred in 2, 5, 2 and 5 cases, respectively, but were eliminated after treatment.Corticosteroid therapy is likely effective and safe for MCD-IgAN patients. |
| Databáze: | OpenAIRE |
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