Reproducibility of anterior chamber angle analyses with the swept-source optical coherence tomography in young, healthy Caucasians
| Autor: | Hellen C S Römkens, Tos T. J. M. Berendschot, Henny J. M. Beckers, Carroll A.B. Webers, Marc Frusch, John de Brabander |
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| Přispěvatelé: | Oogheelkunde, RS: NUTRIM - R1 - Metabolic Syndrome, RS: MHeNs - R3 - Neuroscience |
| Rok vydání: | 2014 |
| Předmět: |
Male
Pathology medicine.medical_specialty Anterior Chamber Coefficient of variation Expert analysis Iris Anterior chamber angle White People Cornea Young Adult Optical coherence tomography Medicine Humans Prospective Studies Iridocorneal angle Observer Variation Reproducibility medicine.diagnostic_test Fourier Analysis business.industry Significant difference Reproducibility of Results Healthy Volunteers Female business Nuclear medicine Random intercept Tomography Optical Coherence |
| Zdroj: | Investigative Ophthalmology & Visual Science, 55(6), 3999-4004. Association for Research in Vision and Ophthalmology |
| ISSN: | 1552-5783 0146-0404 |
| Popis: | PURPOSE: To assess the reproducibility of iridocorneal angle (ICA) analysis in young, healthy Caucasian subjects using swept-source optical coherence tomography (SS-OCT) by determining variability and interobserver agreement between expert and nonexpert observers. METHODS: Thirty-one healthy volunteers (nonexperts) acquired three consecutive SS-OCT images of the right eyes of their peer nonexperts. Images were analyzed by 31 nonexperts and additionally by three experts, whereby the angle opening distance (AOD) and the trabecular iris space area (TISA) at 500 and 750 mum were calculated. A random intercept model was used to determine the amount of variation between observers. In addition, the intra-observer variability between nonexperts and experts was calculated by determining the coefficient of variation (CV). RESULTS: A significant difference was found in the expert analysis for the nasal and temporal angle in the AOD500 (P = 0.002), AOD750 (P < 0.01), and TISA750 (P < 0.01), and the values AOD500 (P = 0.025), AOD750 (P = 0.012), and TISA500 (P = 0.010) were significantly larger if nonexperts analyzed SS-OCT images. The CV was only significant larger for nonexperts for AOD500 (11.1% vs. 8.7%, P < 0.01). CONCLUSIONS: This study demonstrated high reproducibility of angle analysis in young, healthy Caucasian subjects using SS-OCT. Nevertheless, nonexperts obtained significant larger values compared with experts, implying that training is a necessary requirement before analyzing SS-OCT images in ophthalmic practice. |
| Databáze: | OpenAIRE |
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