Lateral prefrontal activity as a compensatory strategy for deficits of cortical processing in Attention Deficit Hyperactivity Disorder
| Autor: | Ximena Stecher, Francisco Aboitiz, Leonie Kausel, Pablo Billeke, Vladimir López, Francisco Zamorano, Ximena Carrasco, Jose M. Hurtado, Josefina Larrain |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Male medicine.medical_specialty Science Prefrontal Cortex Audiology behavioral disciplines and activities Cortical processing Article 03 medical and health sciences 0302 clinical medicine Cognition Neuroimaging mental disorders medicine Reaction Time Attention deficit hyperactivity disorder Humans Attention Bipolar disorder Child Brain Mapping Multidisciplinary Functional connectivity Executive functions medicine.disease Magnetic Resonance Imaging 030104 developmental biology Neuropsychiatric disorder Attention Deficit Disorder with Hyperactivity Medicine Orbitofrontal cortex Psychology 030217 neurology & neurosurgery Psychomotor Performance |
| Zdroj: | Scientific Reports, Vol 7, Iss 1, Pp 1-10 (2017) Scientific Reports Scientific Report Artículos CONICYT CONICYT Chile instacron:CONICYT |
| ISSN: | 2045-2322 |
| Popis: | Attention Deficit Hyperactivity Disorder (ADHD) is the most common neuropsychiatric disorder in childhood and is characterized by a delay of cortical maturation in frontal regions. In order to investigate interference control, which is a key function of frontal areas, a functional MRI study was conducted on 17 ADHD boys and 17 typically developing (TD) boys, while solving the multi source interference task (MSIT). This task consists of two conditions, a “congruent condition” and an “incongruent condition”. The latter requires to inhibit information that interferes with task-relevant stimuli. Behavioral results showed that ADHD subjects committed more errors than TD children. In addition, TD children presented a larger MSIT effect -a greater difference in reaction times between the incongruent and the congruent conditions- than ADHD children. Associated to the MSIT effect, neuroimaging results showed a significant enhancement in the activation of the right lateral prefrontal cortex (rlPFC) in ADHD than in TD subjects. Finally, ADHD subjects presented greater functional connectivity between rlPFC and bilateral orbitofrontal cortex than the TD group. This difference in connectivity correlated with worse performance in both groups. Our results could reflect a compensatory strategy of ADHD children resulting from their effort to maintain an adequate performance during MSIT. |
| Databáze: | OpenAIRE |
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