Diseases caused by defects of energy level and loss of coherence in living cells
| Autor: | Anna Jandová, Jan Pokorný, Jiří Pokorný, Jitka Kobilková, Martina Nedbalová, Aleš Čoček, František Jelínek, Jan Vrba, Alena Dohnalová, Jitka Kytnarová, Jack A. Tuszyński, Alberto Foletti |
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| Rok vydání: | 2015 |
| Předmět: |
Cell Survival
T-Lymphocytes Lactate dehydrogenase-elevating virus Biophysics Medicine (miscellaneous) Biology Virus Mice chemistry.chemical_compound Antigen Pregnancy Immunity Lactate dehydrogenase medicine Animals Humans Disease Mitosis Immunity Cellular Strain (chemistry) Cancer General Medicine medicine.disease Phenotype chemistry Immunology Female Energy Metabolism |
| Zdroj: | Electromagnetic Biology and Medicine. 34:151-155 |
| ISSN: | 1536-8386 1536-8378 |
| DOI: | 10.3109/15368378.2015.1036076 |
| Popis: | Human and animal diseases are brought about by pathological alterations of production, composition, and conformation of macromolecules and structures in cells. Additional contributing factors include changes in physiological states caused by disturbances of energy supply, energy transduction, energy dissipation in moving or oscillating parts, and parasitic energy consumption. Disturbances of energy states may endanger existence of the system. The cell-mediated immunity (CMI) response of T lymphocytes correlating with their adherence properties was examined using antigen prepared from the serum of inbred laboratory mice strain C3H H(2k) infected with lactate dehydrogenase elevating (LDH) virus. LDH virus is a parasite on the cellular energy system. Significant CMI response was elicited in T lymphocytes prepared from the blood of patients with cancer of different phenotypes, acute myocardial infarctions, schizophrenia, and recurrent spontaneous abortions in early pregnancy from unknown reasons. The CMI response is assumed to monitor transferred information about decreased levels of energy states and decoherence in the cells caused by mitochondrial malfunction, parasitic consumption, production of lactate, and possibly other disturbances. The LDH virus infection or similar pathological processes caused by different agents might be connected with the diseases and monitored by the examined CMI response. A large amount of mitoses with chromosome defects in aborted fetuses suggest increased mutability of genomes caused by defective energy states. |
| Databáze: | OpenAIRE |
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