Inhibin a-subunit gene expression in the ovaries of immature female rats is stimulated by pregnant mare serum gonadotrophin
| Autor: | R.G. Forage, Judith A. Clements, Fiona Dench, Irene Nikolaidis, Susan R. Davis, Zygmunt S. Krozowski, Henry G. Burger |
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| Rok vydání: | 1986 |
| Předmět: |
endocrine system
medicine.medical_specialty Inhibin a Transcription Genetic endocrine system diseases Gonadotropins Equine Biophysics Uterus Biology Biochemistry Corpus Luteum Transcription (biology) Placenta Complementary DNA Internal medicine medicine Animals Inhibins RNA Messenger Molecular Biology reproductive and urinary physiology Messenger RNA Ovary Age Factors Cell Biology female genital diseases and pregnancy complications Rats medicine.anatomical_structure Pregnant mare serum Endocrinology Gene Expression Regulation Female Subunit gene hormones hormone substitutes and hormone antagonists |
| Zdroj: | Biochemical and Biophysical Research Communications. 138:1191-1195 |
| ISSN: | 0006-291X |
| DOI: | 10.1016/s0006-291x(86)80408-9 |
| Popis: | We have used a bovine cDNA probe for the A-subunit of inhibin to demonstrate the presence of inhibin in the ovaries of immature female rats: the levels of mRNA were increased following treatment of the rats with pregnant mare serum gonadotrophin (PMSG), suggesting modulation by PMSG of ovarian inhibin synthesis at least at the level of transcription. Furthermore, we report the unexpected finding of significant levels of inhibin mRNA in the corpora lutea of mature female rats. No inhibin mRNA was demonstrable in the uterus or placenta. |
| Databáze: | OpenAIRE |
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