Protective efficacy of a recombinant plague vaccine when co-administered with another sub-unit or live attenuated vaccine
| Autor: | Richard W. Titball, Margret Morton, Simon G. P. Funnell, Diane Williamson, Robert J. Phillpotts, Richard Bedford, Kate F. Griffin, Kate Townson |
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| Rok vydání: | 2005 |
| Předmět: |
Microbiology (medical)
Yersinia pestis Ty21a Immunology Anthrax Vaccines Vaccines Attenuated Plague (disease) Microbiology Subclass Encephalitis Virus Venezuelan Equine Mice Immune system Animals Immunology and Allergy Medicine Vaccines Combined Mice Inbred BALB C Plague Plague Vaccine Vaccines Synthetic Attenuated vaccine biology business.industry Yersiniosis Viral Vaccines General Medicine medicine.disease Antibodies Bacterial Virology Infectious Diseases Immunoglobulin G Vaccines Subunit biology.protein Plague vaccine Female Immunization Antibody business |
| Zdroj: | FEMS Immunology & Medical Microbiology. 43:425-430 |
| ISSN: | 1574-695X 0928-8244 |
| DOI: | 10.1016/j.femsim.2004.10.012 |
| Popis: | Vaccines against bioterrorism agents offer the prospect of providing high levels of protection against airborne pathogens. However, the diversity of the bioterrorism threat means that it may be necessary to use several vaccines simultaneously. In this study we have investigated whether there are changes to the protective immune response to a recombinant sub-unit plague vaccine when it is co-administered with other sub-unit or live attenuated vaccines. Our results indicate that the co-administration of these vaccines did not influence the protection afforded by the plague vaccine. However, the co-administration of the plague sub-unit vaccine with a live vaccine resulted in markedly increased levels of IgG2a subclass antibodies, and markedly reduced levels of IgG1 subclass antibodies, to the plague sub-unit vaccine. This finding might have implications when considering the co-administration of other vaccine combinations. |
| Databáze: | OpenAIRE |
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