CD158k/KIR3DL2 Is a New Phenotypic Marker of Sezary Cells: Relevance for the Diagnosis and Follow-Up of Sezary Syndrome
| Autor: | Alessandro Moretta, Armand Bensussan, Valérie Schiavon, Ewa Poszepczynska-Guigné, Hamid Echchakir, Philippe Musette, Nicolas Ortonne, Michel D'Incan, Martine Bagot, Laurence Boumsell |
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| Rok vydání: | 2004 |
| Předmět: |
CD158k
Skin Neoplasms Receptors Antigen T-Cell alpha-beta T cell Population Dermatology Biochemistry Flow cytometry KIR3DL2 Receptors KIR Antigen Biomarkers Tumor medicine Humans Sezary Syndrome Lymphocytes cutaneous lymphoma Receptors Immunologic education Molecular Biology Sezary Cell Tumor marker education.field_of_study medicine.diagnostic_test business.industry Receptors KIR3DL2 Cell Biology Flow Cytometry Phenotype medicine.anatomical_structure Sezary cells Receptors KIR2DL2 tumor marker Immunology business CD8 Follow-Up Studies |
| Zdroj: | Journal of Investigative Dermatology. 122:820-823 |
| ISSN: | 0022-202X |
| Popis: | CD158k molecules belong to the family of killer cell immunoglobulin-like receptors (KIR) that are expressed on a minor population of circulating NK and CD8+ T lymphocytes. Here, we report a strong positive correlation between the percentage of CD158k+ blood lymphocytes analyzed by flow cytometry and the percentage of atypical circulating cells (Sezary cells) determined by cytomorphology in a large group of patients with Sezary syndrome. Moreover, we show that circulating CD4+CD158k+ lymphocytes correspond to the malignant clonal cell population. Our findings suggest that the CD158k marker could be a useful tool for the evaluation of the circulating tumoral burden and the follow-up of patients with Sezary syndrome. |
| Databáze: | OpenAIRE |
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