Tumor to cervical spinal cord standardized uptake ratio (SUR) improves the reproducibility of 18F-FDG-PET based tumor segmentation in head and neck squamous cell carcinoma in a multicenter setting

Autor: Wim J.G. Oyen, Sven van den Bosch, Frank J. P. Hoebers, Tim Dijkema, Marielle E.P. Philippens, Chris H.J. Terhaard, Johannes H.A.M. Kaanders
Přispěvatelé: Radiotherapie, RS: GROW - R3 - Innovative Cancer Diagnostics & Therapy
Rok vydání: 2019
Předmět:
Male
medicine.medical_treatment
Radiotherapy Planning
UPTAKE VALUES
Uptake ratio
Squamous Cell Carcinoma of Head and Neck/diagnostic imaging
030218 nuclear medicine & medical imaging
Cohort Studies
Segmentation
0302 clinical medicine
Computer-Assisted/methods
FDG-PET
Head and neck cancer
SUR
Hematology
Middle Aged
CANCER
Tumor Burden
VARIABILITY
medicine.anatomical_structure
Oncology
030220 oncology & carcinogenesis
Regression Analysis
Female
Standardized uptake ratio
Rare cancers Radboud Institute for Health Sciences [Radboudumc 9]
Adult
Standardized uptake value
Rare cancers Radboud Institute for Molecular Life Sciences [Radboudumc 9]
METABOLISM
03 medical and health sciences
All institutes and research themes of the Radboud University Medical Center
Journal Article
medicine
Humans
RECONSTRUCTION
Radiology
Nuclear Medicine and imaging
Radiotherapy Planning
Computer-Assisted/methods
Aged
Retrospective Studies
Fluorodeoxyglucose F18/pharmacokinetics
Reproducibility
ACQUISITION
business.industry
Reproducibility of Results
Head and neck squamous cell carcinoma
Retrospective cohort study
QUANTIFICATION
medicine.disease
Spinal cord
Head and neck squamous-cell carcinoma
Radiation therapy
DEFINITION
Cervical Cord/diagnostic imaging
Head and Neck Neoplasms/diagnostic imaging
Radiopharmaceuticals/pharmacokinetics
VOLUME
Nuclear medicine
business
Positron Emission Tomography Computed Tomography/methods
Zdroj: Radiotherapy and Oncology, 130, 39-45. Elsevier Ireland Ltd
Radiotherapy and Oncology, 130, 39-45
Radiotherapy and Oncology, 130, pp. 39-45
Radiotherapy & Oncology, 130, 39. Elsevier Ireland Ltd
ISSN: 0167-8140
DOI: 10.1016/j.radonc.2018.06.037
Popis: Background: In quantitative FDG-PET data analysis, normalization of the standardized uptake value (SUV) with an internal image-derived standard improves its reproducibility. In this study, the cervical spinal cord is proposed as an internal standard that is within the field of view of the radiotherapy planning PET/CT-scan in head and neck cancer. The aim is to evaluate if the tumor to cervical spinal cord standardized uptake ratio (SUR) can improve the reproducibility of a model to determine the metabolic tumor volume (MTV) on FDG-PET/CT in a multicenter setting.Materials and methods: Ninety-five radiotherapy planning FDG-PET/CT-scans of patients with head and neck cancer were analyzed using the Bland-Altman method to evaluate differences in FDG-uptake in the cervical spinal cord and the mediastinal blood pool. Non-linear regression analysis was used to determine the optimal MTV using the gross tumor volume (GTV) as ground truth and a spatial overlap-index as statistical validation metric. Reproducibility was evaluated using the Bland-Altman method and external validation was performed in an independent dataset consisting of 62 patients.Results: Bland-Altman's analyses demonstrated equivalence of FDG-uptake in the mediastinal blood pool and the cervical spinal cord. Reproducibility of the models improved when using SUR instead of SUV. These results were confirmed in the validation cohort.Conclusion: The use of the tumor to cervical spinal cord SUR instead of SUV improves the reproducibility of a model to determine the MTV on FDG-PET/CT in a multicenter setting. This study indicates that SUR may be preferred over SUV based approaches. (C) 2018 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
Databáze: OpenAIRE
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