Structure-Guided Design of Potent Spirocyclic Inhibitors of Severe Acute Respiratory Syndrome Coronavirus-2 3C-like Protease

Autor:	Chamandi S. Dampalla, Athri D. Rathnayake, Anushka C. Galasiti Kankanamalage, Yunjeong Kim, Krishani Dinali Perera, Harry Nhat Nguyen, Matthew J. Miller, Trent K. Madden, Hunter R. Picard, Hayden A. Thurman, Maithri M. Kashipathy, Lijun Liu, Kevin P. Battaile, Scott Lovell, Kyeong-Ok Chang, William C. Groutas
Rok vydání:	2022
Předmět:	Cysteine Endopeptidases SARS-CoV-2 Drug Discovery Molecular Medicine COVID-19 Humans Protease Inhibitors Hepatitis C Chronic Antiviral Agents Pandemics Coronavirus 3C Proteases Peptide Hydrolases
Zdroj:	Journal of medicinal chemistry. 65(11)
ISSN:	1520-4804
Popis:	The worldwide impact of the ongoing COVID-19 pandemic on public health has made imperative the discovery and development of direct-acting antivirals aimed at targeting viral and/or host targets. SARS-CoV-2 3C-like protease (3CL
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e38cfbb5ab002c494a881639063e91ab https://pubmed.ncbi.nlm.nih.gov/35638577 Zobrazit plný text záznamu