Selection of Reference Regions to Model Neurodegeneration in Huntington Disease by 18F-FDG PET/CT Using Imaging and Clinical Parameters
| Autor: | Diego Alfonso López Mora, Alejandro Fernández, Jaime Kulisevsky, Frederic Sampedro, Valle Camacho, Albert Flotats, J. Duch, Jesús Pérez-Pérez, Ignasi Carrió, Saul Martinez-Horta, Francisco Fuentes, Montserrat Estorch, Anna Domènech, Juan Marín-Lahoz |
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| Rok vydání: | 2019 |
| Předmět: |
Adult
Male computer.software_genre 030218 nuclear medicine & medical imaging Cuneus White matter 03 medical and health sciences statistical parametric mapping 0302 clinical medicine modeling neurodegeneration Fluorodeoxyglucose F18 Region of interest Voxel Positron Emission Tomography Computed Tomography Basal ganglia Humans Medicine Radiology Nuclear Medicine and imaging reference region business.industry Parietal lobe Brain General Medicine Huntington disease Middle Aged Reference Standards F-18-FDG PET/CT Pons Huntington Disease medicine.anatomical_structure Frontal lobe reference cluster 030220 oncology & carcinogenesis Female Radiopharmaceuticals Nuclear medicine business computer |
| Zdroj: | CLINICAL NUCLEAR MEDICINE r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau instname |
| ISSN: | 1536-0229 0363-9762 |
| DOI: | 10.1097/rlu.0000000000002329 |
| Popis: | Objective Normalization to an appropriate reference region in F-18-FDG PET imaging may enhance diagnostic performance in Huntington disease (HD). We aimed to identify stable brain areas that could be used to model neurometabolic degeneration in HD correlating imaging (SUVr(values) at the basal ganglia [BBGG]) and clinical parameters (disease burden score [DBS]). Materials and Methods We performed brain F-18-FDG PET/CT in 38 manifest HD patients (mean(age) +/- SD, 54 +/- 14.3 years; CAG(repeats) +/- SD, 44.2 +/- 3.1), 20 premanifest HD patients (mean(age) +/- SD, 42.7 +/- 11.7 years; CAG(repeats) +/- SD, 40 +/- 3.8), and 18 healthy controls (NC; mean(age) +/- SD, 45 +/- 13.2 years). For quantitative analysis, we selected (a) defined reference regions from the Montreal Neurological Institute space atlas (pons, whole cerebellum, cerebral white matter, thalamus, and a pons-cerebellar vermis region of interest), and (b) reference clusters obtained by voxelwise statistical comparison across groups (P < 0.05 FWE; extent voxel threshold k = 200). Each candidate reference region and reference cluster was quantitatively assessed using imaging and clinical parameters. Results Comparing HD and NC groups, we obtained a reference cluster in the cerebellum, and in temporal and frontal lobes. Comparing manifest HD and premanifest HD patients, we observed reference clusters in the cerebellum, pons, thalamus, parietal lobe, and cuneus. The set of reference regions showed a significant correlation between SUVr(values) at the BBGG and DBS in all HD patients. In premanifest HD patients, the correlation between SUVr(values) at the BBGG and DBS was significant using the pons-cerebellar vermis region of interest, the thalamus as defined reference regions, and the pons and thalamus as reference clusters. In manifest HD patients, the correlation was significant using the temporal and white matter frontal lobe clusters. Variance between SUVr(values) in the set of reference regions and reference clusters was minimal within NC. Conclusions The pons may be a stable and reliable region to calculate SUVr(values) to model the neurometabolic degeneration in quantitative F-18-FDG PET imaging in HD. |
| Databáze: | OpenAIRE |
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