Extracorporeal Cardiopulmonary Resuscitation:A National Study on the Association Between Favorable Neurological Status and Biomarkers of Hypoperfusion, Inflammation, and Organ Injury
| Autor: | Emilie Gregers, Sivagowry Rasalingam Mørk, Louise Linde, Jo Bønding Andreasen, Morten Smerup, Jesper Kjærgaard, Peter Hasse Møller-Sørensen, Lene Holmvang, Steffen Christensen, Christian Juhl Terkelsen, Mariann Tang, Jacob Eifer Møller, Jens Flensted Lassen, Henrik Schmidt, Lars Peter Riber, Matilde Winther-Jensen, Sisse Thomassen, Helle Laugesen, Christian Hassager, Helle Søholm |
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| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: |
Adult
Inflammation General Medicine Critical Care and Intensive Care Medicine Cardiopulmonary Resuscitation Out-of-Hospital Cardiac Arrest/therapy Lactates Humans Cardiopulmonary Resuscitation/methods Cardiology and Cardiovascular Medicine Out-of-Hospital Cardiac Arrest Biomarkers Retrospective Studies |
| Zdroj: | Gregers, E, Mørk, S R, Linde, L, Andreasen, J B, Smerup, M, Kjærgaard, J, Møller-Sørensen, P H, Holmvang, L, Christensen, S, Terkelsen, C J, Tang, M, Møller, J E, Lassen, J F, Schmidt, H, Riber, L P, Winther-Jensen, M, Thomassen, S, Laugesen, H, Hassager, C & Søholm, H 2022, ' Extracorporeal Cardiopulmonary Resuscitation : A National Study on the Association Between Favorable Neurological Status and Biomarkers of Hypoperfusion, Inflammation, and Organ Injury ', European Heart Journal: Acute Cardiovascular Care, vol. 11, no. 11, pp. 808-817 . https://doi.org/10.1093/ehjacc/zuac135 Gregers, E, Mørk, S R, Linde, L, Andreasen, J B, Smerup, M, Kjaergaard, J, Møller-Sørensen, P H, Holmvang, L, Christensen, S, Terkelsen, C J, Tang, M, Møller, J E, Lassen, J F, Schmidt, H, Riber, L P, Winther-Jensen, M, Thomassen, S A, Laugesen, H, Hassager, C & Søholm, H 2022, ' Extracorporeal Cardiopulmonary Resuscitation: A National Study on the Association Between Favorable Neurological Status and Biomarkers of Hypoperfusion, Inflammation, and Organ Injury ', European Heart Journal: Acute Cardiovascular Care . https://doi.org/10.1093/ehjacc/zuac135 Gregers, E, Mørk, S R, Linde, L, Andreasen, J B, Smerup, M, Kjærgaard, J, Møller-Sørensen, P H, Holmvang, L, Christensen, S, Terkelsen, C J, Tang, M, Møller, J E, Lassen, J F, Schmidt, H, Riber, L P, Winther-Jensen, M, Thomassen, S, Laugesen, H, Hassager, C & Søholm, H 2022, ' Extracorporeal Cardiopulmonary Resuscitation : A National Study on the Association Between Favorable Neurological Status and Biomarkers of Hypoperfusion, Inflammation, and Organ Injury ', European Heart Journal: Acute Cardiovascular Care, vol. 11, no. 11, zuac135, pp. 808-817 . https://doi.org/10.1093/ehjacc/zuac135 |
| DOI: | 10.1093/ehjacc/zuac135 |
| Popis: | Aims In refractory out-of-hospital cardiac arrest (OHCA) with prolonged whole-body ischaemia, global tissue injury proceeds even after establishment of circulation with extracorporeal cardiopulmonary resuscitation (ECPR). We aimed to investigate the role of biomarkers reflecting hypoperfusion, inflammation, and organ injury in prognostication of patients with refractory OHCA managed with ECPR. Methods and results This nationwide retrospective study included 226 adults with refractory OHCA managed with ECPR in Denmark (2011–2020). Biomarkers the first days after ECPR-initiation were assessed. Odds ratio of favourable neurological status (Cerebral Performance Category 1–2) at hospital discharge was estimated by logistic regression analyses. Cut-off values were calculated using the Youden’s index. Fifty-six patients (25%) survived to hospital discharge, 51 (91%) with a favourable neurological status. Factors independently associated with favourable neurological status were low flow time Conclusion Biomarkers of hypoperfusion (lactate), inflammation (leucocytes), and organ injury (ALP and CK-MB) were independently associated with neurological status at hospital discharge. Biomarkers of hypoperfusion and inflammation (at hospital admission) and organ injury (days 1 and 2 after ECPR) may aid in the clinical decision of when to prolong or terminate ECPR in cases of refractory OHCA. |
| Databáze: | OpenAIRE |
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