Targeting Cannabinoid Receptors: Current Status and Prospects of Natural Products

Autor: Louise Antonia Hendrickx, Jan Tytgat, Dongchen An, Steve Peigneur
Rok vydání: 2020
Předmět:
Cannabinoid receptor
INVERSE AGONIST TARANABANT
OVERWEIGHT PATIENTS
Chemistry
Multidisciplinary

Review
animal venoms
lcsh:Chemistry
Drug Discovery
Cannabinoid receptor type 2
PEPTIDE
Receptor
Receptors
Cannabinoid

lcsh:QH301-705.5
Spectroscopy
Drug discovery
General Medicine
Endocannabinoid system
Computer Science Applications
Molecular Docking Simulation
Chemistry
CB2 RECEPTOR
Physical Sciences
SELECTIVE ANTAGONIST
lipids (amino acids
peptides
and proteins)

synthetic cannabinoids
Life Sciences & Biomedicine
medicine.drug
Biochemistry & Molecular Biology
Biology
Selective antagonist
ENDOCANNABINOID SYSTEM
Catalysis
Inorganic Chemistry
Synthetic cannabinoids
ALLOSTERIC MODULATORS
medicine
Animals
Humans
structural analysis
Physical and Theoretical Chemistry
phytocannabinoids
Molecular Biology
Cannabinoid Receptor Antagonists
Cannabinoid Receptor Agonists
Biological Products
Science & Technology
Animal Sources
Cannabinoids
Organic Chemistry
IN-VITRO
cannabinoid receptor type 1 (CB1) and type 2 (CB2)
SYNAPTIC-TRANSMISSION
lcsh:Biology (General)
lcsh:QD1-999
RECOGNITION MEMORY
Peptides
Neuroscience
Zdroj: International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 21, Iss 5064, p 5064 (2020)
ISSN: 1422-0067
Popis: Cannabinoid receptors (CB1 and CB2), as part of the endocannabinoid system, play a critical role in numerous human physiological and pathological conditions. Thus, considerable efforts have been made to develop ligands for CB1 and CB2, resulting in hundreds of phyto- and synthetic cannabinoids which have shown varying affinities relevant for the treatment of various diseases. However, only a few of these ligands are clinically used. Recently, more detailed structural information for cannabinoid receptors was revealed thanks to the powerfulness of cryo-electron microscopy, which now can accelerate structure-based drug discovery. At the same time, novel peptide-type cannabinoids from animal sources have arrived at the scene, with their potential in vivo therapeutic effects in relation to cannabinoid receptors. From a natural products perspective, it is expected that more novel cannabinoids will be discovered and forecasted as promising drug leads from diverse natural sources and species, such as animal venoms which constitute a true pharmacopeia of toxins modulating diverse targets, including voltage- and ligand-gated ion channels, G protein-coupled receptors such as CB1 and CB2, with astonishing affinity and selectivity. Therefore, it is believed that discovering novel cannabinoids starting from studying the biodiversity of the species living on planet earth is an uncharted territory. ispartof: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES vol:21 issue:14 ispartof: location:Switzerland status: published
Databáze: OpenAIRE
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