Targeting Cannabinoid Receptors: Current Status and Prospects of Natural Products
Autor: | Louise Antonia Hendrickx, Jan Tytgat, Dongchen An, Steve Peigneur |
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Rok vydání: | 2020 |
Předmět: |
Cannabinoid receptor
INVERSE AGONIST TARANABANT OVERWEIGHT PATIENTS Chemistry Multidisciplinary Review animal venoms lcsh:Chemistry Drug Discovery Cannabinoid receptor type 2 PEPTIDE Receptor Receptors Cannabinoid lcsh:QH301-705.5 Spectroscopy Drug discovery General Medicine Endocannabinoid system Computer Science Applications Molecular Docking Simulation Chemistry CB2 RECEPTOR Physical Sciences SELECTIVE ANTAGONIST lipids (amino acids peptides and proteins) synthetic cannabinoids Life Sciences & Biomedicine medicine.drug Biochemistry & Molecular Biology Biology Selective antagonist ENDOCANNABINOID SYSTEM Catalysis Inorganic Chemistry Synthetic cannabinoids ALLOSTERIC MODULATORS medicine Animals Humans structural analysis Physical and Theoretical Chemistry phytocannabinoids Molecular Biology Cannabinoid Receptor Antagonists Cannabinoid Receptor Agonists Biological Products Science & Technology Animal Sources Cannabinoids Organic Chemistry IN-VITRO cannabinoid receptor type 1 (CB1) and type 2 (CB2) SYNAPTIC-TRANSMISSION lcsh:Biology (General) lcsh:QD1-999 RECOGNITION MEMORY Peptides Neuroscience |
Zdroj: | International Journal of Molecular Sciences International Journal of Molecular Sciences, Vol 21, Iss 5064, p 5064 (2020) |
ISSN: | 1422-0067 |
Popis: | Cannabinoid receptors (CB1 and CB2), as part of the endocannabinoid system, play a critical role in numerous human physiological and pathological conditions. Thus, considerable efforts have been made to develop ligands for CB1 and CB2, resulting in hundreds of phyto- and synthetic cannabinoids which have shown varying affinities relevant for the treatment of various diseases. However, only a few of these ligands are clinically used. Recently, more detailed structural information for cannabinoid receptors was revealed thanks to the powerfulness of cryo-electron microscopy, which now can accelerate structure-based drug discovery. At the same time, novel peptide-type cannabinoids from animal sources have arrived at the scene, with their potential in vivo therapeutic effects in relation to cannabinoid receptors. From a natural products perspective, it is expected that more novel cannabinoids will be discovered and forecasted as promising drug leads from diverse natural sources and species, such as animal venoms which constitute a true pharmacopeia of toxins modulating diverse targets, including voltage- and ligand-gated ion channels, G protein-coupled receptors such as CB1 and CB2, with astonishing affinity and selectivity. Therefore, it is believed that discovering novel cannabinoids starting from studying the biodiversity of the species living on planet earth is an uncharted territory. ispartof: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES vol:21 issue:14 ispartof: location:Switzerland status: published |
Databáze: | OpenAIRE |
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