Development of the rectal dosage form with silver-coated glass beads for local-action applications in lower sections of the gastrointestinal tract
Autor: | Jakub Fichna, Hubert Zatorski, Leszek Klimek, Artur Owczarek, Bożena Karolewicz, Krzysztof Siczek |
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Rok vydání: | 2017 |
Předmět: |
Pathology
medicine.medical_specialty Silver Anti-Inflammatory Agents Pharmaceutical Science Context (language use) Suppository Pharmacology Gut flora digestive system 030226 pharmacology & pharmacy Excipients Rectal dosage form 03 medical and health sciences Drug Delivery Systems 0302 clinical medicine Administration Rectal medicine Dosage Forms Inflammation Gastrointestinal tract biology Chemistry General Medicine biology.organism_classification Gastrointestinal Tract Drug delivery 030211 gastroenterology & hepatology Glass |
Zdroj: | Pharmaceutical Development and Technology. 23:295-300 |
ISSN: | 1097-9867 1083-7450 |
Popis: | Recent findings indicating the anti-inflammatory action of silver preparations through modulation of the gut microbiota and apoptosis of inflammatory cells predestine silver use in inflammatory bowel disease (IBD).The aim of our study was to validate the possibility of effective silver release from silver-coated glass beads for anti-inflammatory local application in the lower sections of the gastrointestinal (GI) tract.Silver-coated glass beads were prepared using magnetron method. Release of silver from the silver-coated glass bead surface was carried out in BIO-DIS reciprocating cylinder apparatus. Erosion of silver coating and indirect estimation of the silver release dynamics was assessed using scanning electron microscope. Rectal suppositories containing silver-coated glass beads were prepared using five different methods (M1-M5) and X-ray scanned for their composition.The XR microanalysis and the chemical composition analysis evidenced for a rapid (within 30 min) release of nearly 50% of silver from the coating of the glass beads, which remained stable up to 24 h of incubation. The most homogeneous distribution of beads in the entire volume of the suppository was obtained for formulation M5, where the molten base was poured into mold placed in an ice bath, and the beads were added after 10 s.Our study is the first to present the concept of enclosing silver-coated glass beads in the lipophilic suppository base to attenuate inflammation in the lower GI tract and promises efficient treatment with reduced side effects. |
Databáze: | OpenAIRE |
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