Globus pallidus internus neuronal activity: a comparative study of linear and non-linear features in patients with dystonia or Parkinson’s disease
| Autor: | M. K. Sanghera, Robert G. Grossman, Xingxing Jin, Joachim K. Krauss, Mesbah Alam, R. M. Stewart, Joseph Jankovic, Kerstin Schwabe, J. Song, Olivier Darbin, Götz Lütjens, C. von Wrangel |
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| Rok vydání: | 2015 |
| Předmět: |
Male
0301 basic medicine Deep brain stimulation Movement disorders Parkinson's disease medicine.medical_treatment Globus Pallidus 03 medical and health sciences 0302 clinical medicine Basal ganglia medicine Humans Premovement neuronal activity Pallidotomy Biological Psychiatry Aged Neurons Dystonia Parkinson Disease Middle Aged medicine.disease nervous system diseases Electrophysiology Psychiatry and Mental health 030104 developmental biology Globus pallidus nervous system Neurology Female Neurology (clinical) medicine.symptom Psychology Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Journal of Neural Transmission. 123:231-240 |
| ISSN: | 1435-1463 0300-9564 |
| Popis: | Movement disorders such as Parkinson's disease (PD) and dystonia are associated with alterations of basal ganglia motor circuits and abnormal neuronal activity in the output nucleus, the globus pallidus internus (GPi). This study aims to compare the electrophysiological hallmarks for PD and dystonia in the linear and non-linear time stamp domains in patients who underwent microelectrode recordings during functional stereotactic surgery for deep brain stimulation (DBS) or pallidotomy. We analyzed single-unit neuronal activity in the posteroventral lateral region of the GPi in awake patients prior to pallidotomy or the implantation of DBS electrodes in 29 patients with PD (N = 83 neurons) and 13 patients with dystonia (N = 41 neurons) under comparable conditions. The discharge rate and the instantaneous frequency of the GPi in dystonia patients were significantly lower than in PD patients (P |
| Databáze: | OpenAIRE |
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