Stem and progenitor cells in sebaceous gland development, homeostasis and pathologies
| Autor: | Catherin Niemann, Anna Geueke |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Sebaceous gland Dermatology Biology Biochemistry Skin Diseases 030207 dermatology & venereal diseases 03 medical and health sciences Mice Sebaceous Glands 0302 clinical medicine medicine Animals Homeostasis Humans Secretion Progenitor cell Molecular Biology Acne integumentary system Stem Cells Holocrine medicine.disease Cell biology 030104 developmental biology medicine.anatomical_structure Stem cell Hair Follicle Ex vivo |
| Zdroj: | Experimental dermatologyREFERENCES. 30(4) |
| ISSN: | 1600-0625 |
| Popis: | Sebaceous glands (SGs), typically associated with hair follicles, are critical for the homeostasis and function of mammalian skin. The main physiological function of SGs is the production and holocrine secretion of sebum to lubricate and protect the skin. Defective SGs have been linked to a variety of skin disorders, including acne, seborrheic dermatitis and formation of sebaceous tumors. Thus, a better understanding how SGs are formed and maintained is important to unravel the underlying molecular and cellular mechanisms of SG pathologies and to find better and effective therapies. Over the last two decades, research has come a long way from the initial identification of skin epithelial stem cells to the isolation and functional characterization of multiple stem cell pools as well as a better understanding of their unique and complex activities that drive skin homeostasis and operate in skin pathologies. Here, we discuss recent progress in unravelling cellular mechanisms underlying SG development, homeostasis and sebaceous tumor formation and assess the role of stem and progenitor cells in controlling SG physiology and disease processes. The development of elegant in vivo imaging as well as various in vitro and ex vivo stem cell and SG tissue models will advance mechanistic studies on SG function and allow drug screening and testing for efficient and successful targeting SG pathologies. |
| Databáze: | OpenAIRE |
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