Longitudinal changes of left ventricular filling pressure and N-terminal pro-brain natriuretic peptide on chronic hemodialysis
| Autor: | Song Hc, Park Cs, Shin Sj, Kim Ys, Kim Hy, Kim Yk, Sang-Hyun Ihm, Yang Cw, Hong Ty, Choi Ej |
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| Rok vydání: | 2010 |
| Předmět: |
Nephrology
Male medicine.medical_specialty medicine.drug_class medicine.medical_treatment Doppler echocardiography Statistics Nonparametric Renal Dialysis Internal medicine Natriuretic Peptide Brain medicine Natriuretic peptide Ventricular Pressure Humans Chronic hemodialysis cardiovascular diseases Prospective Studies skin and connective tissue diseases medicine.diagnostic_test business.industry General Medicine Blood Pressure Monitoring Ambulatory Middle Aged medicine.disease Brain natriuretic peptide Prognosis Echocardiography Doppler Peptide Fragments Surgery Cardiology Disease Progression Kidney Failure Chronic Regression Analysis Female Hypertrophy Left Ventricular sense organs Hemodialysis Ventricular filling business Kidney disease |
| Zdroj: | Clinical nephrology. 74(3) |
| ISSN: | 0301-0430 |
| Popis: | Background: Left ventricular filling pressure (LVFP) is related to the long-term prognosis in end-stage renal disease. The aims of this study were to evaluate the time course of the changes in LVFP, the predictors for the changes of LVFP, and the plasma N-terminal pro-brain natriuretic peptide (NT-proBNP) levels as indicators for the changes of LVFP in chronic hemodialysis (HD). Methods: This study was designed prospectively. Doppler echocardiographic examinations and measurement of plasma NT-proBNP levels were performed in 37 consecutive patients on chronic HD and repeated at median of 43 months later. A ratio of peak early transmitral flow velocity to peak early diastolic mitral annular velocity (E/Em), an estimate of LVFP, was calculated. Results: E/Em ratios were significantly increased during the follow-up period. In multivariate analysis, age and changes of LVMI were independently associated with the changes of E/Em ratios. The plasma NT-proBNP levels were independently associated with E/Em at baseline and at the end of follow-up. The changes of plasma NT-proBNP levels were independently associated with changes of E/Em ratios (β-coefficient 0.453, p = 0.003). Conclusions: Our data suggest that the deterioration of LVFP parallels with the progression of LV hypertrophy. Monitoring the plasma NT-proBNP levels might be useful for the detection of the LVFP changes in chronic HD. |
| Databáze: | OpenAIRE |
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