Coronary artery calcification scoring system based on the coronary artery calcium data and reporting system (CAC-DRS) predicts major adverse cardiovascular events or all-cause death in patients with potentially curable lung cancer without a history of cardiovascular disease

Autor: Kazuhiro Osawa, Masamichi Tanaka, Hiroshi Ito, Akihiro Bessho, Asako Mizobuchi, Hironori Saito, Soichiro Fuke, Akihisa Yumoto, Shunsuke Daido, Shigeharu Moriyama
Rok vydání: 2020
Předmět:
Adult
Male
medicine.medical_specialty
Lung Neoplasms
Computed Tomography Angiography
Coronary Artery Disease
030204 cardiovascular system & hematology
Coronary Angiography
Risk Assessment
Severity of Illness Index
03 medical and health sciences
0302 clinical medicine
Japan
Predictive Value of Tests
Carcinoma
Non-Small-Cell Lung
Internal medicine
Multidetector Computed Tomography
medicine
Humans
Registries
cardiovascular diseases
030212 general & internal medicine
Myocardial infarction
Vascular Calcification
Lung cancer
Stroke
Aged
Retrospective Studies
business.industry
Proportional hazards model
Incidence
Incidence (epidemiology)
Hazard ratio
Cancer
Middle Aged
Prognosis
medicine.disease
Cardiac surgery
Heart Disease Risk Factors
Cardiology
Female
Cardiology and Cardiovascular Medicine
business
Zdroj: Heart and Vessels. 35:1483-1493
ISSN: 1615-2573
0910-8327
Popis: The coronary artery calcium data and reporting system (CAC-DRS) is a novel reporting system based on CAC severity. Lung cancer patients have a high risk of cardiovascular disease (CVD), for which CAC severity may provide additional prognostic information. Using non-gated, non-contrast computed tomography (CT), we evaluated the CAC-DRS for predicting CVD and all-cause death in patients with potentially curable resected lung cancer. We retrospectively studied 309 consecutive patients without a history of CVD (mean age 67.4 ± 8.2 years, 61% male) who underwent curative surgery for non-small-cell lung cancer between May 2012 and March 2019 at the Japanese Red Cross Okayama Hospital. Time to incidence of major adverse cardiac events (MACEs) (non-fatal myocardial infarction, non-fatal stroke and cardiovascular death) and all-cause death was analyzed using Fine and Gray and Cox regression models. The CAC-DRS score was assessed using standard chest CT without electrocardiogram gating. During 52-months’ median follow-up, 43 patients (13.4%) developed incident MACEs or died from any cause; the pathological cancer stages were Ia (n = 20), Ib (n = 8), IIa (n = 2), IIb (n = 2) and IIIa (n = 11). Patients had a graded increase in incidence of MACEs or all-cause death with increasing categories of CAC-DRS. The CAC-DRS score was significantly associated with incident MACEs or all-cause death after adjusting for confounding factors (hazard ratio 1.18; 95% confidence interval 1.10–1.25, p
Databáze: OpenAIRE
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