The Influence of Diabetes Mellitus on Survival of Abdominal Perforator Flaps: An Experimental Study in Rats with Slowly Induced Diabetes Mellitus
| Autor: | B. Baldea, Radu Olariu, Alexandru Valentin Georgescu, Dan Ovidiu Grigorescu, Simona Barsan, Septimiu Toader, Marius Penciu, Andras Nagy, Pavel Orbai |
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| Rok vydání: | 2014 |
| Předmět: |
medicine.medical_specialty
Body weight Diabetes Mellitus Experimental Random Allocation Epigastric artery Diabetes mellitus Skin Ulcer medicine Animals Complication rate Rats Wistar Pancreas Glycemic Tissue Survival Wound Healing business.industry Dermis medicine.disease Streptozotocin Surgery Complication business Perforator Flap Perforator flaps medicine.drug |
| Zdroj: | Journal of Reconstructive Microsurgery. 31:145-153 |
| ISSN: | 1098-8947 0743-684X |
| DOI: | 10.1055/s-0034-1394101 |
| Popis: | Lower limb ulcers are a major source of morbidity and mortality in diabetic patients. Surgical coverage of these wounds is fraught with a high complication rate. Although clinically perforator flaps lead to good results in diabetic patients, there is little experimental data to support this finding.A total of 60 Wistar rats were randomly assigned either to the diabetic (n = 30) or control (n = 30) group. Diabetes was induced by streptozotocin injection at 50 mg/kg body weight and was confirmed by blood glucose levels180 mg/dL preoperatively. In all rats, a cranial epigastric artery perforator flap was raised. At postoperative day 7, all flaps were raised, photographed by digital planimetry, and analyzed histologically.Mean glycemic levels preoperatively were 207.8 ± 16 in the diabetic group and 82.8 ± 5.1 in the control group (p0.05). Ninety percent of the flaps survived completely in the control group, compared with 66.7% in the diabetic group (p0.05). The mean flap survival area was lower in the diabetic group (83.3 ± 16.5%) than in the control group (96 ± 4%). There were significantly more perioperative complications in the diabetic group (46.7%) than in the control group (16.7%), but these did not affect flap survival. Superficial ulceration appeared only in the diabetic group as a complication.Perforator flaps can be successfully used for coverage of cutaneous defects in a rat diabetic model. These flaps show higher complication rates in diabetic versus nondiabetic animals; however, this complication rate has little influence on flap survival. |
| Databáze: | OpenAIRE |
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