Local inflammatory reaction to benign, pre-malignant and malignant glottic lesions: A matched case-control study
| Autor: | Maya Shats, Yonatan Lahav, Hagit Shoffel-Havakuk, Yaara Haimovich, Meir Warman, Doron Halperin, Monica Huszar |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Male
Pathology medicine.medical_specialty Glottis Malignancy Lesion Laryngeal Diseases 03 medical and health sciences 0302 clinical medicine Carcinoma medicine Cytotoxic T cell Humans 030223 otorhinolaryngology Laryngeal Neoplasms Retrospective Studies CD20 Inflammation biology Laryngoscopy CD68 business.industry Middle Aged medicine.disease Otorhinolaryngology 030220 oncology & carcinogenesis Case-Control Studies biology.protein Carcinoma Squamous Cell Immunohistochemistry Female medicine.symptom Neoplasm Grading business Precancerous Conditions CD8 Biomarkers |
| Zdroj: | Clinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-LaryngologyCervico-Facial Surgery. 44(4) |
| ISSN: | 1749-4486 |
| Popis: | OBJECTIVES To study the inflammatory infiltrates associated with the different stages of laryngeal carcinogenesis. DESIGN Observational, matched case-control study of histopathologic specimens. SETTING An academic referral centre. PARTICIPANTS A total of 45 patients who underwent removal of glottic lesions between 2008 and 2015. Patients were enrolled and categorised into three matched groups according to lesions' histopathologic diagnoses, 15 patients in each group: benign, pre-malignant and squamous cell carcinoma (SCC). Matching was based on age, gender and pack-years. MAIN OUTCOME MEASURES Immunohistochemistry staining using monoclonal antibodies against CD4, CD8, CD68, CD20 and S100 representing T-helper cells, cytotoxic T cells, macrophages, B cells and dendritic cells, respectively. Cell counts and distributions were measured and compared between groups. Correlations between the different cells were examined. RESULTS The predominant cell type was CD8+, followed by CD68+ and CD4+. All inflammatory cells increased significantly in number in SCC (P-value |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text