Liver disease and the e antigen in HBsAg carriers with chronic renal failure
| Autor: | G. P. Coughlin, A P Disney, A G Wangel, J Hay, A G Van Deth |
|---|---|
| Rok vydání: | 1980 |
| Předmět: |
Male
Cirrhosis Chronic liver disease Hepatitis Hepatitis B Antigens Liver disease Antigen Medicine Humans Hepatitis B Surface Antigens business.industry Transmission (medicine) Chronic Active Liver Diseases Gastroenterology Hepatitis B medicine.disease Prognosis Immunology Acute Disease Carrier State Chronic Disease Kidney Failure Chronic Female business Research Article |
| Zdroj: | Gut. 21(2) |
| ISSN: | 0017-5749 |
| Popis: | This study was undertaken to assess the frequency of development and the stages of evolution of chronic liver disease in patients with renal failure who are chronic carriers of hepatitis B surface antigen. Cirrhosis or chronic active hepatitis developed in five of 21 patients and could not be predicted by the initial histological appearance or by HLA-A and B typing but was associated with the e antigen in four of the five patients. However, the antigen was not a consistent indicator of a poor prognosis, as the four other e antigen positive patients did not develop chronic liver disease during the period of the study. Transmission of hepatitis B to spouses occurred in four cases, was fatal in one instance, and was associated with e antigen in three of the four. Determination of e antigen status in renal unit patients who are carriers of hepatitis B surface antigen may be of value to the patient and his home environment. |
| Databáze: | OpenAIRE |
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