Death by association: BH3 domain-only proteins and liver injury
| Autor: | G. J. Gores, Edwina S. Baskin-Bey |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
Programmed cell death
Physiology Cell Apoptosis Biology Mitochondrion Apoptotic Process Physiology (medical) medicine Animals bcl-2-Associated X Protein Liver injury Hepatology Liver Diseases Liver cell Neuropeptides Bcl-2 family Gastroenterology medicine.disease Rats Cell biology bcl-2 Homologous Antagonist-Killer Protein medicine.anatomical_structure Proto-Oncogene Proteins c-bcl-2 Hepatocytes biological phenomena cell phenomena and immunity Apoptosis Regulatory Proteins |
| Zdroj: | American Journal of Physiology-Gastrointestinal and Liver Physiology. 289:G987-G990 |
| ISSN: | 1522-1547 0193-1857 |
| DOI: | 10.1152/ajpgi.00371.2005 |
| Popis: | Apoptosis, a prominent form of cell death, is a prime feature of many acute and chronic liver diseases. Apoptosis requires mitochondrial dysfunction, which is regulated by proteins of the Bcl-2 family. Whether or not a cell should live or die is controlled by the interaction of multidomain Bcl-2 proteins with proapoptotic BH3 domain-only proteins of this family. Current models suggest multidomain, antiapoptotic Bcl-2 proteins prevent mitochondrial dysfunction by sequestering and/or preventing activation of its proapoptotic relatives. BH3-only proteins initiate cell death by neutralizing and or ligating multidomain prosurvival Bcl-2 proteins. Thus BH3 domain-only proteins are paramount in the apoptotic process as exemplified by the role of the BH3 domain-only protein Bid in liver injury. In this concise review, we will focus on how these BH3 domain-only proteins are regulated in the cell, their association with the Bcl-2 family of proteins, and finally, current information regarding their involvement in liver cell apoptosis and injury. |
| Databáze: | OpenAIRE |
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