Heterogeneity of Endocrinologic and Metabolic Parameters in Reproductive Age Polycystic Ovary Syndrome (PCOS) Women Concerning the Severity of Hyperandrogenemia—A New Insight on Syndrome Pathogenesis
| Autor: | Agnieszka Szmyt, Marcin Korman, Katarzyna Ożegowska, Leszek Pawelczyk |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Adult
Hirsutism medicine.medical_specialty metabolic disturbances endocrine system diseases Health Toxicology and Mutagenesis lcsh:Medicine 030209 endocrinology & metabolism Article Body Mass Index Anovulation hyperandrogenism Young Adult 03 medical and health sciences 0302 clinical medicine Insulin resistance Internal medicine Follicular phase medicine Humans Testosterone hirsutism Dyslipidemias 030219 obstetrics & reproductive medicine free testosterone medicine.diagnostic_test Dehydroepiandrosterone Sulfate business.industry Polycystic ovary syndrome (PCOS) Hyperandrogenism lcsh:R Public Health Environmental and Occupational Health nutritional and metabolic diseases Luteinizing Hormone medicine.disease Polycystic ovary female genital diseases and pregnancy complications Endocrinology polycystic ovary syndrome Female Insulin Resistance business Lipid profile |
| Zdroj: | International Journal of Environmental Research and Public Health Volume 17 Issue 24 International Journal of Environmental Research and Public Health, Vol 17, Iss 9291, p 9291 (2020) |
| ISSN: | 1660-4601 |
| DOI: | 10.3390/ijerph17249291 |
| Popis: | Background: Polycystic ovary syndrome (PCOS) is characterized by hyperandrogenism, anovulation, infertility, obesity, and insulin resistance, which results in increased concentrations of testosterone (T), which disturbs follicular growth and ovulation. This study aimed to assess PCOS women&rsquo s clinical, endocrinological, and metabolic parameters concerning hyperandrogenism severity. Results: 314 women (mean age 27.3 ± 4.6 mean body mass index (BMI) 25.7 ± 5.6) with PCOS, were divided into terciles according to T concentrations: < 0.64 ng/mL (group 1), 0.64 to 0.84 ng/mL (Group 2) and > 0.84 ng/mL (group 3). The mean concentration of T in all women was 0.59 ng/mL and correlated negatively with the number of menstrual cycles per year (MPY) (r = &minus 0.36 p < 0.0001) and positively with Ferriman-Gallway score (FG) (r = 0.33 0.0001), luteinizing hormone (LH) (r = 0.19 0.0001) and dehydroepiandrosterone sulfate (DHEAS) (r = 0.52 0.0001). Positive correlation between BMI and hirsutism (r = 0.16 0.0001), total cholesterol (TC) (r = 0.18 0.0001), low-density lipoprotein (LDL) (r = 0.29 0.0001), and triglycerides (TG) (r = 0.40 0.0001) was demonstrated. The division into subgroups confirmed the lowest MPY, highest LH, and hirsutism in group 3. BMI, insulin sensitivity indices, and lipid profile parameters were not different between the three T subgroups. Conclusions: We found no correlation between testosterone levels and insulin sensitivity or dyslipidemia in women with PCOS. Metabolic abnormalities may contribute more significantly than hyperandrogenemia to PCOS development. |
| Databáze: | OpenAIRE |
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