Biological evaluations of fatty acid esters originated during storage of Prasaplai, a Thai traditional medicine
| Autor: | Wandee Gritsanapan, Prasan Tangyuenyongwatana |
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| Rok vydání: | 2007 |
| Předmět: |
Palmitates
Oleic Acids Herpesvirus 1 Human Plant Science Biology Biochemistry Analytical Chemistry Mycobacterium tuberculosis Inhibitory Concentration 50 chemistry.chemical_compound Chlorocebus aethiops Animals Humans Inhibitory concentration 50 Cytotoxicity Vero Cells chemistry.chemical_classification Chromatography Molecular Structure Fatty Acids Organic Chemistry Fatty acid Fatty acid ester Esters biology.organism_classification Anti hsv 1 Linoleic Acids chemistry Vero cell Medicine Traditional |
| Zdroj: | Natural Product Research. 21:990-997 |
| ISSN: | 1478-6427 1478-6419 |
| Popis: | Three fatty acid esters, (E)-4-(3,4-dimethoxyphenyl)but-3-en-1-yl linoleate (1), (E)-4-(3,4-dimethoxyphenyl)but-3-en-1-yl oleate (2), and (E)-4-(3,4-dimethoxyphenyl)but-3-en-1-yl palmitate (3), originated during storage by the interaction of components in Prasaplai, were synthesized. These three artificial esters were subjected to four biological evaluations. All three compounds were active against Mycobacterium tuberculosis H(37)Ra for which compounds 1 and 3 had inhibitory concentration at 200 microg mL(-1) while compound 2 inhibited at 100 microg mL(-1). When all these compounds were subjected to anti-HSV-1 test, compound 2 showed positive activity at 42.6 microg mL(-1) without any cytotoxic activity against human vero cell line while compound 3 had the cytotoxicity to vero cell at IC(50) 38 microg mL(-1). Compound 1 was inactive for this test. |
| Databáze: | OpenAIRE |
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