Smoking in Patients with Parkinson's Disease: preliminary striatal DaT-SPECT findings
| Autor: | G. Iliceto, Giuseppe Rubini, Maria Superbo, G. Defazio, A. Niccoli Asabella, Daniele Liuzzi, Cristina Ferrari, Angelo Fabio Gigante, Paolo Livrea |
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| Rok vydání: | 2015 |
| Předmět: |
0301 basic medicine
Male medicine.medical_specialty Neurology Parkinson's disease Movement Caudate nucleus 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Image Processing Computer-Assisted Humans Psychiatry Aged Tomography Emission-Computed Single-Photon Dopamine Plasma Membrane Transport Proteins Putamen Dopaminergic Smoking Parkinson Disease General Medicine Odds ratio Middle Aged medicine.disease Confidence interval Corpus Striatum 030104 developmental biology Cross-Sectional Studies Cardiology Female Neurology (clinical) Occipital Lobe Radiopharmaceuticals Psychology Occipital lobe 030217 neurology & neurosurgery Tropanes |
| Zdroj: | Acta neurologica Scandinavica. 134(4) |
| ISSN: | 1600-0404 |
| Popis: | Objective To assess whether cigarette smoking interferes with dopaminergic transmission in current- and never-smoking patients with Parkinson's disease. Materials and methods Striatal [123I]FP–CIT single photon emission computed tomography was performed in 67 patients with Parkinson's disease (35 women and 32 men aging 60.8 ± 10.1 years and staging 1.76 ± 0.5 on the Hoehn and Yahr scale). At study time, there were 13 current-smokers and 54 never-smokers. Results Current-smokers showed a significantly lower putamen/occipital [123I]FP–CIT ratio and a non-significant trend to a lower caudate/occipital [123I]FP–CIT ratio uptake. Current-smokers were also characterized by a lower off UPDRS-III motor score. A logistic regression analysis adjusted for age, sex, disease duration, Hoehn and Yahr staging, and medication indicated a significant lower [123I]FP–CIT uptake not only in the putamen (odds ratio, 0.1; 95% confidence interval, 0.01 to 0.65; P = 0.02) but also in the caudate (odds ratio, 0.2; 95% confidence interval, 0.04 to 0.71; P = 0.015) as well as a lower UPDRS-III motor score (odds ratio, 0.9; 95% confidence interval, 0.81 to 0.99; P = 0.04) in current-smokers. Conclusions The lower [123I]FP-CIT uptake together with the lower UPDRS-III motor score observed in our current-smokers patients with Parkinson's disease (even taking into account variables that are probably expression of dopaminergic neuron decline and treatment) would support an effect of smoking on dopaminergic synaptic mechanisms. |
| Databáze: | OpenAIRE |
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