Radiofrequency ablation versus resection for hepatocellular carcinoma in patients with Child-Pugh A liver cirrhosis: a meta-analysis
| Autor: | Jemianne Bautista Jia, Johannes M. Ludwig, D. Zhang, H.S. Kim |
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| Rok vydání: | 2017 |
| Předmět: |
Liver Cirrhosis
medicine.medical_specialty Cirrhosis Carcinoma Hepatocellular Radiofrequency ablation Medizin Gastroenterology Disease-Free Survival law.invention 03 medical and health sciences 0302 clinical medicine law Internal medicine Carcinoma medicine Humans Radiology Nuclear Medicine and imaging In patient Survival analysis business.industry Liver Neoplasms General Medicine Odds ratio Middle Aged medicine.disease Survival Analysis 030220 oncology & carcinogenesis Meta-analysis Hepatocellular carcinoma Catheter Ablation 030211 gastroenterology & hepatology business |
| Zdroj: | Clinical radiology. 72(12) |
| ISSN: | 1365-229X |
| Popis: | Aim To evaluate whether radiofrequency ablation (RFA) or surgical resection (RES) has superior overall survival (OS) and disease-free survival (DFS) in patients with hepatocellular carcinoma and Child–Pugh class A liver cirrhosis. Materials and methods Meta-analysis was used to compare 1-, 3-, and 5-year OS and DFS between RFA and RES. Those studies meeting inclusion criteria and published prior to 1 June 2015 were included. The odds ratio (OR) was used as the treatment effect measure. A priori defined sensitivity analyses of study subgroups was performed. Results: Fifteen studies were included in this analysis. Subgroup analyses based on predetermined patient characteristics were performed to minimise bias. No difference in 1-year OS, 3-year OS, and 3-year DFS was found in analyses limited to studies where patients were equally eligible for both therapies. There was also not a significant difference in OS and DFS between RFA and RES when studies were limited to those with only solitary tumours or tumours Conclusion The data suggest the equivalence of RFA and RES in patients with solitary tumours |
| Databáze: | OpenAIRE |
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