Mapping MHC-Resident Transplantation Determinants
| Autor: | Effie W. Petersdorf, Mary M. Horowitz, Ted Gooley, Machteld Oudshoorn, Frank T. Christiansen, L. Absi, Eliane Gluckman, A. Dormoy, Michael Haagenson, Katia Gagne, Jan J. Cornelissen, Valérie Dubois, Mari Malkki, Stephen R. Spellman |
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| Přispěvatelé: | Hematology, Erasmus School of Health Policy & Management |
| Rok vydání: | 2007 |
| Předmět: |
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Oncology Linkage disequilibrium medicine.medical_specialty medicine.medical_treatment Graft vs Host Disease Hematopoietic stem cell transplantation Histocompatibility Testing Article Linkage Disequilibrium Major Histocompatibility Complex Predictive Value of Tests Internal medicine medicine Humans Transplantation Homologous Survival analysis Retrospective Studies Transplantation Polymorphism Genetic Hematopoietic cell transplantation business.industry Hazard ratio Hematopoietic Stem Cell Transplantation Microsatellite Hematology Odds ratio Survival Analysis Confidence interval Treatment Outcome Immunology Female MHC business Microsatellite Repeats |
| Zdroj: | Biology of Blood and Marrow Transplantation, 13(8), 986-995. Elsevier Inc. |
| ISSN: | 1083-8791 |
| DOI: | 10.1016/j.bbmt.2007.05.007 |
| Popis: | Graft-versus-host disease (GVHD) accounts for increased morbidity and mortality after HLA-identical unrelated hematopoietic cell transplantation (HCT). To test the hypothesis that the major histocompatibility complex (MHC) encodes functional variation other than the classical HLA genes, we measured risks associated with donor-recipient MHC microsatellite (Msat) marker mismatching in 819 HCT recipients and their HLA-A, -B, -C, -DRB1, and -DQB1 allele-matched unrelated donors. Suggestive trends of association with transplant outcome were observed for 5 Msats. Donor-recipient mismatching for the extended class I D6S105, class III D6S2787, and class II D6S2749 markers was each associated with an increased risk of death (hazard ratio, 1.32; 95% confidence interval, 1.02-1.71; P = .03; hazard ratio, 1.26; 95% confidence interval, 1.03-1.53; P = .02; hazard ratio, 1.37; 95% confidence interval, 1.08-1.72; P = .007, respectively) whereas mismatching for the class I D6S2811 marker was associated with a decreased risk of death (hazard ratio, 0.80; 95% confidence interval, 0.66-0.98; P = .03). Mismatching for the class I D6S265 marker was associated with a decreased risk of grades III-IV acute GVHD (odds ratio, 0.67; 95% confidence interval, 0.45-0.98; P = .04). These results suggest that Msats may be informative for mapping MHC-resident genetic variation of clinical importance in HCT. |
| Databáze: | OpenAIRE |
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