The correlation among the percentage of positive biopsy cores from the dominant side of prostate, adverse pathology, and biochemical failure after radical prostatectomy
| Autor: | Ozgur Ugurlu, Alp Özgür Akdemir, Binhan Kagan Aktas, Ali Memis, Cetin Volkan Oztekin, Cüneyt Özden |
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| Rok vydání: | 2011 |
| Předmět: |
Male
Pathology medicine.medical_specialty Turkey Biopsy medicine.medical_treatment Urology Adenocarcinoma Prostate cancer Predictive Value of Tests Risk Factors Retropubic prostatectomy Prostate Biomarkers Tumor medicine Humans Aged Neoplasm Staging Retrospective Studies Cancer Prostatectomy Medicine(all) lcsh:R5-920 medicine.diagnostic_test business.industry Biopsy Needle Prostatic Neoplasms Seminal Vesicles General Medicine Middle Aged Prostate-Specific Antigen medicine.disease Prostate-specific antigen medicine.anatomical_structure Multivariate Analysis Prostate surgery Neoplasm Recurrence Local Positive Surgical Margin lcsh:Medicine (General) business Radical retropubic prostatectomy |
| Zdroj: | Kaohsiung Journal of Medical Sciences, Vol 27, Iss 8, Pp 307-313 (2011) |
| ISSN: | 2410-8650 1607-551X |
| DOI: | 10.1016/j.kjms.2011.03.009 |
| Popis: | The aim of this study was to evaluate the correlation among various preoperative clinical variables, including certain prostate needle biopsy parameters, biochemical failure, and adverse pathology, after radical retropubic prostatectomy (RRP). We retrospectively evaluated the records of our 156 patients who underwent RRP because of localized prostate cancer. Serum prostate-specific antigen level, clinical stage, and the information obtained from biopsy [Gleason score, number of positive cores, percentage of positive cores (PPCs) from the dominant side of prostate, and overall PPC] were evaluated as predictors of adverse pathology and biochemical failure. Of the patients, 30.2% (n=38) had nonorgan-confined disease, 19.1% (n=24) had positive surgical margins, 11.9% (n=15) had positive seminal vesicle invasion, and 16.7% (n=21) had biochemical failure after RRP. Multivariate analysis demonstrated that a PPC value of 55% or more from the dominant side of prostate is the only independent predictor of nonorgan-confined disease and seminal vesicle invasion. Clinical stage (T2b), biopsy Gleason score, and PPC values of 55% or more from the dominant side of prostate were found to be statistically significant predictors of positive surgical margin and biochemical failure. Our results support that PPC from the dominant side of prostate is a useful parameter for the prediction of adverse pathology and biochemical failure after RRP. |
| Databáze: | OpenAIRE |
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