The role of antibodies in myasthenia gravis
| Autor: | Maurice H. W. Stassen, M. De Baets |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
Autoimmune disease
biology business.industry Autoantibody Disease Receptors Nicotinic medicine.disease Myasthenia gravis Nervous System Autoimmune Disease Experimental nervous system diseases Neurology Antigen immune system diseases Myasthenia Gravis Immunology biology.protein Humans Medicine Neurology (clinical) Antibody business Receptor Autoantibodies Acetylcholine receptor |
| Zdroj: | Journal of the Neurological Sciences. 202:5-11 |
| ISSN: | 0022-510X |
| DOI: | 10.1016/s0022-510x(02)00200-9 |
| Popis: | Myasthenia gravis is an autoimmune disease associated with antibodies directed to the postsynaptic acetylcholine receptor. These antibodies reduce the number of receptors. Autoantibodies against AChR and other muscle antigens can be used for the diagnosis of myasthenia gravis and related disorders. The origin and the role of these antibodies in the disease are discussed. Experimental autoimmune myasthenia gravis, an experimental model closely mimicking the disease, has provided answers to many questions about the role of antibodies, complement macrophages and AChR anchor proteins. Genetically modified anti-AChR antibodies may also be used in the future to treat myasthenia. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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