Association between genetic polymorphisms and osteonecrosis in steroid treatment populations: a detailed stratified and dose-response meta-analysis

Autor: Jun Yang, Xiaoge Yang, Ming Jing
Rok vydání: 2019
Předmět:
0301 basic medicine
Oncology
Apolipoprotein B
Logistic regression
Biochemistry
single nucleotide polymorphisms
0302 clinical medicine
Femur Head Necrosis
Child
Research Articles
Aged
80 and over
education.field_of_study
biology
Incidence
Middle Aged
Methylprednisolone
030220 oncology & carcinogenesis
Meta-analysis
Prednisolone
Steroids
medicine.drug
Research Article
Adult
medicine.medical_specialty
ATP Binding Cassette Transporter
Subfamily B
Adolescent
Population
Biophysics
Single-nucleotide polymorphism
Polymorphism
Single Nucleotide
03 medical and health sciences
Young Adult
Internal medicine
medicine
SNP
Humans
Genetic Predisposition to Disease
education
Molecular Biology
Aged
Apolipoproteins B
business.industry
Cell Biology
030104 developmental biology
biology.protein
Prednisone
business
meta analysis
Zdroj: Bioscience Reports
ISSN: 1573-4935
0144-8463
DOI: 10.1042/bsr20190024
Popis: Steroid treatment has become recognized as an important risk factor for avascular osteonecrosis of the femoral head. However, not all patients who receive long-term, high-dose steroids develop osteonecrosis, indicating that there are individual differences in occurrence. We explored the relationship between polymorphisms and steroid-induced osteonecrosis of the femoral head (SONFH) incidence with variables. We used a multilevel mixed-effects logistic regression model, which is an expansion of logistic regression, for each type of steroid, primary disease, drug dose, applied duration, and single-nucleotide polymorphism (SNP). We also conducted a dose-response meta-analysis to analyze the cumulative dosage and SONFH risk in mutation carriers. There were significant correlations between the ABCB1 rs1045642 mutant and SONFH in the prednisone-use and methylprednisolone/prednisone-use populations. The ABCB1 rs2032582 mutant homozygote had a protective effect in the methylprednisolone/prednisolone renal transplant population. For ApoB rs693, mutation increased the incidence of SONFH in prednisone-use and methylprednisolone/prednisolone-use populations and renal transplant patients. For ApoB rs1042031, mutation increased the risk of SONFH in the prednisone-use population. The PAI-1 rs1799768 mutation had a protective effect on the SONFH risk prednisone-use and renal transplant populations. ABCB1 rs1045642 mutations have a protective effect against SONFH, and ApoB rs693 and rs1042031 increase the SONFH risk. Cumulative dosage and treatment duration had little effect on the results. In addition, there was a dose-effect correlation in ABCB1 rs1045642 and rs2032582 mutation carriers.
Databáze: OpenAIRE
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