Identification of Antitumor Activity of Pyrazole Oxime Ethers
| Autor: | Jong-Cheol Lee, Su-Jin Park, Kyung Eun Lee, Bangle Ahn, HeeYeong Cho, Kee-In Lee, Hyun-Ja Park |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
Stereochemistry
Clinical Biochemistry Pyrazolone Pharmaceutical Science Antineoplastic Agents Pyrazole Oxime ether Biochemistry Chemical synthesis Inhibitory Concentration 50 chemistry.chemical_compound Cell Line Tumor Drug Discovery Oximes medicine Humans Doxorubicin Cytotoxicity Molecular Biology Cell Proliferation Antitumor activity Organic Chemistry Biological activity General Medicine Oxime Combinatorial chemistry In vitro chemistry Molecular Medicine Pyrazoles Drug Screening Assays Antitumor Ethers medicine.drug |
| Zdroj: | ChemInform. 36 |
| ISSN: | 1522-2667 0931-7597 |
| DOI: | 10.1002/chin.200542140 |
| Popis: | A series of pyrazole oxime ether derivatives were prepared and examined as cytotoxic agents. In particular, 5-phenoxypyrazole was comparable to doxorubicin, while exhibiting very potent cytotoxicity against XF 498 and HCT15. |
| Databáze: | OpenAIRE |
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