Aprotinin reduces the IL-8 after coronary artery bypass grafting
| Autor: | I Pasaoglu, Metin Demircin, CS Isbir, Ilhan Yaylim, Riza Dogan |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
Adult
Male Bypass grafting medicine.medical_treatment Enzyme-Linked Immunosorbent Assay Myocardial Reperfusion Injury Group A Group B law.invention Aprotinin Postoperative Complications law Cardiopulmonary bypass Humans Medicine Radiology Nuclear Medicine and imaging Interleukin 8 Coronary Artery Bypass Saline Aged business.industry Myocardium Interleukin-8 Middle Aged medicine.anatomical_structure Anesthesia Female Surgery Cardiology and Cardiovascular Medicine business hormones hormone substitutes and hormone antagonists medicine.drug Artery |
| Zdroj: | Cardiovascular Surgery. 9:403-406 |
| ISSN: | 0967-2109 |
| DOI: | 10.1016/s0967-2109(01)00011-4 |
| Popis: | The effect of aprotinin, a protease inhibitor, on myocardial interleukin-8 (IL-8) production after ischemia-reperfusion injury was investigated. Twenty patients who had elective coronary artery bypass grafting were included in this study. Patients were randomly divided into two groups (n = 10 in each). Group A patients received high dose aprotinin (20,000 IU/kg as pretreatment followed by 7500 IU/kg for 6 h) and Group B patients received normal saline as a control. Serum IL-8 levels after the termination of cardiopulmonary bypass (CPB) showed a significant improvement in aprotinin treated group compared to control group (70 +/- 42.6 vs 360.71 +/- 87.9 ng/ml) (P0.005). Levels were also significantly higher at post-operative 24th hour in patients who did not received aprotinin (340.16 +/- 92.10 vs 96.13 +/- 34.33 ng/ml). However at post-operative 48th hour levels were again higher in control (untreated) group, but the difference was not statistically significant (78.8 +/- 34.4 vs 42.8 +/- 9.29 ng/ml). Aprotinin prevented the IL-8 release from myocytes in ischemia-reperfusion injury. The mechanism is highly dependent on anti-protease activity of aprotinin. |
| Databáze: | OpenAIRE |
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