Human C-Reactive Protein Is Protective against FatalSalmonella entericaSerovar Typhimurium Infection in Transgenic Mice
| Autor: | John E. Volanakis, Alexander J. Szalai, William H. Benjamin, Jerry R. McGhee, John L. VanCott |
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| Rok vydání: | 2000 |
| Předmět: |
Male
Salmonella typhimurium Salmonella Immunology Bacteremia Mice Transgenic Spleen medicine.disease_cause Microbiology Immunoglobulin G Mice Immune system Streptococcus pneumoniae medicine Animals Humans Transgenes Pathogen Host Response and Inflammation Salmonella Infections Animal biology biology.organism_classification Antibodies Bacterial Mice Inbred C57BL C-Reactive Protein Infectious Diseases medicine.anatomical_structure Liver Mice Inbred DBA Salmonella enterica biology.protein Parasitology Antibody |
| Zdroj: | Infection and Immunity. 68:5652-5656 |
| ISSN: | 1098-5522 0019-9567 |
| DOI: | 10.1128/iai.68.10.5652-5656.2000 |
| Popis: | C-reactive protein (CRP) is an acute-phase protein with a well-known association with infection and other inflammatory conditions. We have shown that expression of human CRP by CRP transgenic (CRPtg) mice is protective against lethal infection byStreptococcus pneumoniae, an effect likely mediated by CRP's ability to bind to this gram-positive pathogen. In the present study we tested whether CRPtg mice are resistant to infection withSalmonella entericaserovar Typhimurium, a gram-negative pathogen that causes the murine equivalent of typhoid fever. CRPtg mice experimentally infected with a virulent Typhimurium strain lived longer and had significantly lower mortality than their non-tg littermates. The greater resistance of CRPtg mice could be attributed to significantly increased early (0 to 4 h) blood clearance of salmonellae and significantly decreased numbers of bacteria in the liver and spleen on day 7 postinfection. In addition, 14 days after infection with an avirulentSalmonellastrain, the serum titer of anti-Salmonellaimmunoglobulin G antibodies was higher in CRPtg than non-tg mice. This study provides unequivocal evidence that CRP plays an important role in vivo in host defense against salmonellae during the early stages of infection. In addition, as the beneficial effect of CRP includes enhancement of the host's humoral immune response, CRP may also contribute indirectly to host defense during later stages of infection. |
| Databáze: | OpenAIRE |
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