A Randomized Trial of Ciprofloxacin versus Cefixime for Treatment of Gonorrhea after Rapid Emergence of Gonococcal Ciprofloxacin Resistance in The Philippines
| Autor: | King K. Holmes, Gina Dallabetta, Mari Rose Aplasca de los Reyes, Carmelita U. Tuazon, William L. H. Whittington, T Wi, Ricardo Manalastas, Virginia Pato-Mesola, Jeffrey D. Klausner |
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| Rok vydání: | 2001 |
| Předmět: |
Adult
Microbiology (medical) Sexually transmitted disease medicine.medical_specialty Adolescent Philippines Gonorrhea Drug resistance medicine.disease_cause Microbiology Minimum inhibitory concentration Anti-Infective Agents Cefixime Ciprofloxacin Internal medicine medicine Humans Prospective Studies Antibacterial agent business.industry Drug Resistance Microbial medicine.disease Sex Work Neisseria gonorrhoeae Cephalosporins Treatment Outcome Infectious Diseases Female business medicine.drug |
| Zdroj: | Clinical Infectious Diseases. 32:1313-1318 |
| ISSN: | 1537-6591 1058-4838 |
| DOI: | 10.1086/319998 |
| Popis: | From 1994 through 1996-1997, high-level ciprofloxacin resistance (minimum inhibitory concentration [MIC],or = 4.0 microg/mL) increased from 9% to 49% of gonococcal isolates recovered from consecutive female sex workers in Cebu and Manila, The Philippines (P.01). During 1996-1997, 105 female sex workers with gonorrhea were prospectively randomized to receive treatment with oral ciprofloxacin, 500 mg, or cefixime, 400 mg, and followed for test of cure. Neisseria gonorrhoeae was reisolated within 28 days after treatment from 1 (3.8%) of 26 women given cefixime versus 24 (32.3%) of 72 women given ciprofloxacin (P.01). Treatment failure (reisolation of pretreatment auxotype/serovar) occurred in 14 (46.7%) of 30 women infected with strains with MICs of ciprofloxacinor = 4.0 microg/mL versus 1 (3.6%) of 28 infected by strains with MICs4.0 microg/mL (P.01). High-level, clinically significant gonococcal resistance to ciprofloxacin has rapidly emerged in The Philippines, and spread of fluoroquinolone resistance through commercial sex poses a threat to control of gonorrhea and prevention of human immunodeficiency virus infection and the acquired immunodeficiency syndrome. |
| Databáze: | OpenAIRE |
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