High sensitivity, specificity and predictive value of the Connective Tissue Disease Screening Questionnaire among urban African-American women
| Autor: | Elizabeth A. Wright, Ramina Jajoo, Lisa M. Fitzgerald, E Husni, Elena Massarotti, Timothy E. McAlindon, Karen H. Costenbader, Helen Pankey, Patricia A. Fraser, Elizabeth W. Karlson |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
Adult
medicine.medical_specialty Urban Population Population 030204 cardiovascular system & hematology Sensitivity and Specificity White People 03 medical and health sciences 0302 clinical medicine Rheumatology Environmental risk Predictive Value of Tests Risk Factors Internal medicine Surveys and Questionnaires Medicine Humans Lupus Erythematosus Systemic education Caucasian population False Negative Reactions 030203 arthritis & rheumatology African american education.field_of_study business.industry Medical record Hispanic or Latino Middle Aged medicine.disease Connective tissue disease Predictive value Screening questionnaire Black or African American Massachusetts Population Surveillance Physical therapy Female business |
| Zdroj: | Lupus. 14(10) |
| ISSN: | 0961-2033 |
| Popis: | The Connective Tissue Disease Screening Questionnaire (CSQ), developed to screen populations for SLE and other CTDs, has been validated in a predominantly Caucasian population with hospital-based controls. We aimed to test the performance characteristics of the CSQ in an urban, predominantly African-American population. The CSQ was administered by interview to women recruited for a study of environmental risk factors and SLE, including 99 cases with SLE validated by medical record review and 202 healthy controls recruited from the community. Overall, 88% of subjects had African heritage, 6% were Hispanic and 4% were non-Hispanic Caucasian. Controls were more likely to report African heritage than cases (91% versus 82%, P < 0.001). Sensitivity for detecting SLE was 88% and specificity was 91%. In this study, where the prevalence of SLE was 33%, predictive value of a positive CSQ was 82% and predictive value of a negative CSQ was 94%. The CSQ has slightly lower sensitivity but greater specificity for SLE in an urban, predominantly African-American population with community-based controls compared with a Caucasian population with hospital-based controls. These results suggest that the CSQ has adequate sensitivity and specificity and could be used in population studies to screen African-American women for SLE. |
| Databáze: | OpenAIRE |
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