Altered protein expression pattern in skin fibroblasts from parkin -mutant early-onset Parkinson's disease patients

Autor: Rosa Lippolis, Anna Ferretta, Francesco Papa, Consiglia Pacelli, Antonio Gaballo, Salvatore Scacco, Claudia Dell'Aquila, Maria Fiorella Mazzeo, Michele De Mari, Tiziana Cocco, Sergio Papa, Rosa Anna Siciliano
Rok vydání: 2015
Předmět:
Zdroj: Biochimica et biophysica acta. Molecular basis of disease 1852 (2015): 1960–1970. doi:10.1016/j.bbadis.2015.06.015
info:cnr-pdr/source/autori:Rosa Lippolis, Rosa Anna Siciliano b, Consiglia Pacelli c, Anna Ferretta d, Maria Fiorella Mazzeo b, Salvatore Scacco, Francesco Papa, Antonio Gaballo, Claudia Dell'Aquila, Michele De Mari, Sergio Papa, Tiziana Cocco./titolo:Altered protein expression pattern in skin fibroblasts from parkin-mutant early-onset Parkinson's disease patients./doi:10.1016%2Fj.bbadis.2015.06.015/rivista:Biochimica et biophysica acta. Molecular basis of disease/anno:2015/pagina_da:1960/pagina_a:1970/intervallo_pagine:1960–1970/volume:1852
ISSN: 0925-4439
DOI: 10.1016/j.bbadis.2015.06.015
Popis: Parkinson's disease (PD) is the most common neurodegenerative movement disorder caused primarily by selective degeneration of the dopaminergic neurons in substantia nigra. In this work the proteomes extracted from primary fibroblasts of two unrelated, hereditary cases of PD patients, with different parkin mutations, were compared with the proteomes extracted from commercial adult normal human dermal fibroblasts (NHDF) and primary fibroblasts from the healthy mother of one of the two patients. The results show that the fibroblasts from the two different cases of parkin -mutant patients display analogous alterations in the expression level of proteins involved in different cellular functions, like cytoskeleton structure–dynamics, calcium homeostasis, oxidative stress response, protein and RNA processing.
Databáze: OpenAIRE
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