In Vitro Effects of Sporobacterin Probiotic on the Function of Donor Granulocyte-Macrophage Cells
| Autor: | N. I. Gabrielyan, V. S. Suskova, N. L. Vologodskaya, S. I. Suskov |
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| Rok vydání: | 2012 |
| Předmět: |
Adult
Male Free Radicals Enzyme-Linked Immunosorbent Assay In Vitro Techniques Granulocyte General Biochemistry Genetics and Molecular Biology Microbiology law.invention Probiotic Combined treatment Granulocyte-Macrophage Progenitor Cells law medicine Humans Macrophage Organic Chemicals Dose-Response Relationship Drug Chemistry Probiotics General Medicine Oxidative activity Middle Aged In vitro medicine.anatomical_structure Bacterial Vaccines Luminescent Measurements Cytokines Female Sporobacterin Acetylmuramyl-Alanyl-Isoglutamine Function (biology) |
| Zdroj: | Bulletin of Experimental Biology and Medicine. 153:697-699 |
| ISSN: | 1573-8221 0007-4888 |
| Popis: | The effects of sporobacterin probiotic (Bakoren Company) on oxidative activity of donor granulocyte-macrophage cells (GMC) were studied in vitro by luminol-dependent chemiluminescent method, and the effects of the probiotic on the production of pro- and anti-infl ammatory cytokines were evaluated by ELISA. The probiotic dose-dependently stimulated spontaneous production of free radicals by GMC; combined treatment with immunomodulators likopid, polyoxydonium, and IFN-α2a produced a more potent effect. Sporobacterin stimulated the production of pro- and anti-infl ammatory cytokines in cell cultures. These data confi rmed the immunomodulatory effect of sporobacterin, an important component in the phagocytic system cells. |
| Databáze: | OpenAIRE |
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